An Overdue Aclaris Update

I used to cover Aclaris Therapeutics and its topical JAK inhibitor product for androgenetic alopecia fairly regularly. However, there have been few significant recent updates.

Today morning, Aclaris released a summary of its FY 2018 results. The most relevant part for us concerns the ATI-502 topical product for androgenetic alopecia. They also seem to name this product as AGA-201 and ATI-50002.

Per the latest news, Phase 2 open-label clinical trials for ATI-502 (a topical JAK1/3 inhibitor) involve 31 patients with androgenetic alopecia (AGA). Interim 6-month data are expected in the second quarter of 2019, while comprehensive 12-month data will be realized in the second half of 2019.

So by the end of this year, we should finally have at least some idea on whether JAK inhibitors can at least somewhat help patients with AGA (aka male pattern hair loss). The trials will measure both safety and efficacy.

We already know beyond a doubt that JAK inhibitors significantly help people with the less common alopecia areata (AA) and its various related forms (alopecia totalis and alopecia universalis).

30 thoughts on “An Overdue Aclaris Update”

  1. I would prefer stem cells/implants by Shiseido/Riken rather than some sort of regular drug, but if it works I will take it, regardless of risk or price or however far I have to travel to get some.

  2. I think Jak inhibitors are very effective; but the question here /
      Will it be a treatment for a defined period of time or is it life-time like minoxidil?

  3. AFAIK, hope was raised originally because dormant human hair follicles transplanted to mice responded well to JAK inhibitors and began to regrow. However, a mouse does not have a human immune system and the mouse immune system was suppressed with drugs so as not to interfere with the experiment. So the big question is how these drugs will work as they interact with a human immune system and other human enzymes.

  4. Thanks Admin. My hopes are placed on Aclaris and Riken! Very cool that we’ll definitely see some Aclaris results soon.

    Please press Riken for info whenever you get the chance. Dig, like the journalist you are! :-)

  5. Please read my comment in the last post regarding ebv and autoimmune problems and tell me what you think. Jak might not work but they could be on the right track

  6. Where’s NASA RS? He’s like the Sonny the cuckoo cocoa puffs bird for Jak inhibitors with AGA, NASA’s Cuckoo for Jak! I’ll take his unbridled optimism over the opposite mentality or fear mongering any day.

    1. Yoda, Agreed on NASA. I have to remain cautious with my optimism, though. Ever since Aclaris designated AGA treatment “exploratory”, I’m pretty sure that means they’re just exploring the idea (and haven’t seen a viable breakthrough).

      That said, Riken is promising big things in the next couple of years, so I’m praying they’re legit.

  7. Riken is definitely interesting and possibly the holy grail. However, my observations tell me that IF it’s successful it’s more than a couple years away before being commercially available to most all people. And yes, this includes the Japanese market. I have no inside info, no crystal ball and could be wrong, which I hope I am.

  8. Bring on the JAK news, bad or good let’s just know and to plan.

    For something that does not work they sure are spending a great deal of time on it. I think the question is not DOES it work by HOW WELL does it work. A couple of strands of hair OK we will toss it but significant hair now we are talking.

    It’s going to happen in 2019 in the next 3-6 months.

    Funny how some actually FEAR that we might have good results then what do they do? People get used to anything but not me. I want the truth then the treatment.

    You know where I stand.

    1. Adding, Admin keep up the JAK update every month as this information will come out Very Soon and the Results could be Extremely Important.

        1. Drum roll please…it’s Nasa_RS finally with a comment on the JAK update! Is the Pope Catholic, does a bear crap in the woods, the tide goes in, the tide goes out! Yes Admin, there should be a JAK update every month even if there’s absolutely no news. At least we’d get the optimistic stylings of one Mr. Nasa_rs!! :-)

  9. Nasa aren’t you disenchanted with JAK if it arrives at market in 2023 ?

    I would love to buy some on some sketchy internet offshore pharmacy but it’s pretty dangerous right? And the Christian formula is quite particular trade secret in its delivery. So all these things are killing my buzz

    1. Let’s find out IF JAK works and how well. Then it becomes like the movie, It’s a Mad Mad World where everyone here’s about the location of buried treasure then they all take off in all directions trying to get to the same place… placing an order for JAK. Hah.

      I’m a bit optimistic there must be something for them to take this long.

      All my opinion.

  10. https://finance.yahoo.com/news/edited-transcript-acrs-earnings-conference-215835332.html

    There is a little bit of JAK info from Aclaris recent earnings release. In essence (good or bad) in talking about dermatitis it mentions that hair growth can occur when some have this disease. Also states that AA grow hair with topical JAK and no signs of side affects or other issues. Also states they will be excited to release the data once it becomes available for JAK. JAK just seems to work for all different types of hair loss including disease that it probably works for male pattern hairloss is my guess.

    On pure speculation, I think it works just not on everyone that it will not be the complete cure for everyone that it probably greatly increases hair growth and it might take a few years to get a full head of hair. Just my feeling. Although it does not matter we will have the facts in months, by the end of the year but my guess by end of summer.

  11. Its trading around 6 bucks… With a high of 30. If the news is dramatic enough it could quintuple+ again. I might throw down a few k on that around autumn.

    Also I feel like an idiot that I just found out 15 minutes ago aubrey degrey and Michael west launched AgeX on the NYSE. and it briefly quintupled following ipo. That’s an exotic company right there.

    What a day we live in.

  12. As for the recent Replicel ‘First-In-Japan Strategy’:

    Unless Shiseido decides to launch earlier, Replicel is anticipating RCH-01 to be available in Japan by 2022.
    https://www.replicel.com/news/replicel-reignites-its-first-in-japan-strategy

    They next-stage trial will also be in Japan and will, if I’m not mistaken, commence only after they release their dermal injector; so Replicel Phase 2 in 2020 in Japan.

    *looks like I’ll need to work on my chopstick technique*

    1. Toccata, it is an amazing country. One of the best in the 33 countries I have been so lucky to visit. The gadgets are second to none and the crime rate is so low the police in Tokyo spend half their time helping lost tourists.

  13. I have been on the Aclaris ATI-50002 trial for about a year. 6 months was random and this last 6 months was a guaranteed full dose. I was just informed that the results have been very disappointing and Aclaris is halting trials. Oral trials have been successful and will move forward. I don’t think a topical solution will ever work for substantially growth. I was on the trial for alopecia but was also putting the medication on balding areas not affected by alopecia. I honestly had better results with Rogaine foam. I think there is great hope for regrowth with oral JAK type medications if you are willing to monitor your blood regularly for any side effects.

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