Monthly Archives: July 2015

Wake Forest University, Amy McMichael, Anthony Atala

Wake Forest University Hair Loss Research

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Several days ago, I came across a hair loss forum post concerning a study related to a new topical hair loss product. This study was looking for volunteers and is taking place at Wake Forest Baptist Health Medical Center in Winston-Salem, North Carolina.

Update: On the hair loss forums, some people think that this could be related to US army related research. Or to Samumed’s second Phase 2 clinical trial for SM04554, which includes scalp biopsies this time around. This second study is enrolling only 50 volunteers, as opposed to the 300 enrolled the first time around. I feel like the army research makes more sense, since none of the centers listed in Samumed’s latest presentation include any locations in North Carolina. On the other hand, Wake Forest (along with Rutgers University and the University of Pittsburgh) does have a significant relationship with the US army’s regenerative medicine research section.

Until this week, I had not read much about any significant hair loss research being conducted at Wake Forest University. However, the above study made me do some digging around. To my surprise, I found that Wake Forest has a part of its dermatology department dedicated to hair loss and body hair removal research. Moreover, it seems like the dermatology department’s chair Dr. Amy McMichael is especially well versed in women’s hair loss and ethnic hair and skin problems.

I have therefore decided to add Wake Forest University to my list of key hair loss research centers around the world.

Note that Wake Forest is also home to the renowned regenerative medicine researcher Dr. Anthony Atala. His videos on Tedtalk are a must watch. Also see the Wake Forest pages on printing skin cells of burn wounds and on their story.

Akio Sato, Finasteride

Finasteride More Effective on Japanese Men

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Ten Years Finasteride Hair Loss Treatment Before After.
Ten years of Finasteride hair loss treatment before and after. Japanese male.

Update: September 2019 — The same authors (led by Dr. Akio Sato) just published a 10-year update on the below Finasteride study.

Amazingly, Japanese men continued to see new hair growth even after 10 years of Finasteride 1 mg/day use. In fact, many patients even saw new hair growth at the 10 year mark! Furthermore, most patients saw an improvement from year 5 to year 10.

Side effects remained minimal even after such long-term use. One of the patients is seen in the photo on the left at baseline and after each year of treatment.

Finasteride more Effective in Japanese Men

A very important study titled “Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia” was just published in the Journal of Dermatology (it was received in 2014, but released now). Unfortunately, Google Scholar does not have a free version of the study, although I was able to preview the first page here.

Apparently, this was the first major long-term (≥ 5 years) study on oral Finasteride use to treat  hair loss in Japanese men. A major 3-year efficacy study was published in the past that showed improvement in 78 percent of Japanese patients. However, this new five-year study showed improvement in a stunning 99.4 percent of the 810 patients who took 1mg finasteride per day for 5 years or more!

The authors (led by Dr. Akio Sato) conclude that Japanese hair loss sufferers are probably much better responders to Finasteride than are Caucasian men. They cite a prior large-scale 1,553 person study on Caucasian men that showed a 48 percent improvement after 5 years (I am guessing that most of the remainder saw maintenance).

The authors mention that on average, Japanese men bald 10 years later than Caucasian men — and from my own observations, Japanese men also bald far less frequently than Caucasian men. This latest study on Japanese men also showed better responses in those that had less pre-existing baldness and started treatment at a younger age. As is almost always the case with these studies, the side effects from long-term Finasteride use were minimal.

On hair loss forums, you will often read anecdotal reports about persistent relatively serious side effects in some people who have taken Finasteride for a while, and it is up to you and your doctor to decide on whether its worth this risk. I take 1.25mg Finasteride every two days (via cutting Proscar tablets), but may change my dose to 1mg daily in the future.

Shiseido update from Japan

Also from Japan, Shiseido was covered in a local paper (link no longer works) that you need to translate into English. A take on that article from a two-person Canadian-Japanese translation team named “Master Blaster” can be read here.

It seems like Replicel thinks that the cure will be here in 2018, although I will only buy that time-frame once their final clinical trial results come through later this year and show limited side effects as well as positive hair growth results. I am nevertheless very pleased to read about an even more optimistic timeline for a cure than I project on this blog’s name.