The Theradome Laser Helmet for Hair Growth

Theradome PRO LH80 Laser Helmet
Theradome PRO LH80 Laser Helmet for Hair Growth.

You can purchase the wireless Theradome PRO LH80 laser helmet for hair growth from Amazon after reading the customer reviews. It is currently on sale for 10% off.

Also available is the cheaper Theradome EVO LH40. Both devices have a combined 4.3 out of 5 stars average rating as of December 2024, though the PRO LH80 is more popular than the EVO LH40 based on past separate breakouts.

A 2020 study of a helmet-like low-level light therapy (LLLT) device used in balding South Koreans, there was a significant increase in both hair density and hair thickness after 16 weeks of use. The 30  participants who got treated with the laser helmet saw an average increase in hair density of 41.90  hairs/cm2 and an average increase in hair thickness of 7.50 μm. Also read this systemic review of 32 home-use LLLT devices that had been approved by the FDA as of January 2020.

Theradome Laser Helmet

Among the various laser hair growth devices and systems, the Theradome helmet stands out for its unique appearance. Other well known laser helmets include the iRestore and iGrow. On this blog, I interviewed this product’s inventor Dr. Tamim Hamid in 2015.

Since the HairMax Lasercomb first became popular a decade ago, a number of new laser products and contraptions have entered the market. Among these include the Revian Red cap for hair growth.

The Theradome (released in 2013) was the first one that received as much publicity. As of 2020, they now have two models that are discussed further below. More product details and historical information can be seen on the FAQ page on the company website. Also see their Instagram page, their Facebook page and their Twitter/X page for regular updates.

Theradome Laser Helmet
Theradome Laser Helmet for Hair Growth.

Low-Level Laser Hair Growth Popularity

What really strikes me about low-level laser therapy (LLLT) is that so many people are willing to splurge for these devices. The proven benefits of LLLT when it comes to hair growth are limited. Even today, there are disputes about the appropriate wavelength of low-level laser devices.

Theradome raised close to half a million dollars via crowdfunding on Indiegogo in 2013. Quite surprising, considering that it was a new device with few ratings and reviews at the time. On the campaign home page, you can see a tab for number of founders, and the total is 1,266. The vast majority of those names are “anonymous” with no country of origin displayed.

All the people who bid $395 in the campaign were given the laser helmet in return. The campaign’s initial funding goal was $50,000, which I thought as somewhat optimistic. Perhaps my opinion is clouded by seeing the weak results of numerous other kickstarter crowdfunding campaigns.

Theradome EVO LH40 vs. PRO LH80

As of 2024, there are two models of the Theradome available for purchase:

  1. Theradome PRO LH80 with 80 diodes. Priced at around $900. Use for 20 minutes per day, twice a week.
  2. Theradome EVO LH40 with 40 diodes. Price usually around $600. Use for 20 minutes per day, four times a week.

Reviews and Ratings

In the recent past, the Theradome PRO LH80 had 350 reviews on Amazon, averaging 4.2 out of 5 stars. The Theradome EVO LH40 had about 100 reviews, also averaging 4.2 out of 5 stars. As of 2025, the reviews for the two devices have been combined. On Trustpilot, the average rating is an excellent 4.8/5 stars. You can also purchase these laser helmets from Costco.

Theradome FDA Clearance

The Theradome laser is advertised as being the “First and Only FDA OTC Cleared Clinical Strength Laser Hair Therapy for Home Use”. It has been given FDA 510(k) clearance and is not likely to result in any serious side effects with correct use. The device comes with a 1-year warranty, and you can order replacement parts and batteries from the manufacturer.

Clinical trials for the PRO LH80 were completed in December 2016.

For more information, see the manufacturer’s YouTube channel.

Minoxidil Sulfotransferase Booster out in 2023

November 26, 2024

I have added a few new updates in regards to Minoxidil Sulfotransferase booster news. The Rida Hair Research Institute (US) product was removed from Amazon, but is back again on Wal Mart’s site. I am suspicious about its average 5 star review rating. I added the ingredient list for both the Rida and Cosmofix (India) products further below in an image.

A lot of readers are interested in this subject, and perhaps one of them can compare the ingredients. Note that the original manufacturer of the Cosmofix Minoxidil booster is Applied Biology (US), which was acquired by Jupiter Wellness (Safety Shot — US) in 2022; which was in turn acquired by Elite Health Partners (US) in 2024. Also of note, Daniel Alain will soon release a supplement based on natural botanicals that will increases SULT1A1 enzyme levels in hair follicles. Interestingly, in 2020, Daniel Alain acquired a stake in Applied Biology.

September 24, 2023

MinoxiBoost Minoxidil Booster Released

MinoxiBoost
MinoxiBoost from CosmoFix (India). Licensed from Jupiter Wellness (US).

MinoxiBoost solution (60 ml) finally got released in India via Cosmofix. It is currently sold in India via Cutiscart. The official July 25, 2023 launch announcement from Jupiter Wellness (US) mentioned its Indian partners Sanpellegrino Cosmetics and Cosmofix Technovation. The two of them have exclusive distribution rights to this product in 31 countries in Asia and the Middle East.

Note that this product was originally developed by Applied Biology (US). See the bottom part of this post for more details.

Also of interest, a company named Rida Hair Research Institute (US) is selling its own Minoxidil booster spray product on Amazon (Update: Now removed). The call it Mino Boost and it currently has an average rating of 4 out of 5 stars based on 62 reviews. They claim that it will make your topical Minoxidil treatment 7X more effective. The sale of this product began in February 2023 per Rida’s Instagram.

Minoxidil Booster
Minoxidil Booster from Rida Hair.

An oral Minoxidil sulfotransferase enzyme hair supplement is going to soon be sold in the US by Daniel Alain. They used to sell a topical one in the past, but I do not see it on their website anymore. The oral version is based on natural botanicals and will increases SULT1A1 enzyme levels in hair follicles.

Note that compounded Minoxidil Sulfate (MXS) based topical formulations are readily available for medical use in some parts of the world, such as Brazil.

Minoxidil Booster Ingredients

Below is a comparison image that lists the key ingredients in the above two (Rida Hair and Cosmofix) Minoxidil booster products.

  • The top image is the Rida product.
  • The bottom image is the Cosmofix (developed by Applied Biology) product.
  • A third product’s ingredient comparison comes via a comment from “Pinotq”. The topical Minoxidil booster than used to be sold by Daniel Alain had the following ingredients:

“Water, Sodium Bicarbonate, Phosphatidylcholine, Glycerin, PEG-6 Caprylic/Capric Glyceride, Phenoxyethanol, Ethylhexyglycerin, Polysorbate 80, Tetrasodium EDTA, Fragrance”.

The company is now switching to an oral version devised from natural botanicals as I mentioned earlier.

Minoxidil Booster Ingredients
Minoxidil Booster Ingredients. Top image is the Rida Hair product. Bottom image is the Cosmofix product.

January 19, 2023

The Minoxidil Sulfotransferase Enzyme

With oral Minoxidil becoming the most discussed hair loss treatment over the past year, now is a good time to discuss the Minoxidil Sulfotransferase (SULT1A1) enzyme.

The below diagram is from a Polish study published in 2022 covering Sulfotransferase activity in hair follicles and the response to Minoxidil treatment. Sulfotransferase 1A1 is encoded by the SULT1A1 gene.

Minoxidil Sulfotransferase (SULT1A1).
Minoxidil Sulfotransferase (SULT1A1) chemical structure.

When Minoxidil is used topically on the scalp, it is converted into its active form (Minoxidil sulfate) by SULT1A1 enzymes, which are located in the follicular outer root sheath. However, many people’s hair follicles lack high levels of sulfotransferase. So these men (and women) are unable to convert even extra strength Minoxidil into its active form that stimulates hair growth.

Note that Retin-A (Tretinoin) enhances the response to Minoxidil in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. No wonder so many blog readers have recommended the use of both products together.

Benefits for Oral Minoxidil too?

When it comes to oral Minoxidil, the body’s liver does the job of converting Minoxidil into Minoxidil sulfate (also spelled sulphate). Several articles that I read seem to suggest that the hair follicle does not need to do the conversion anymore. However, Dr. John Cole said the following to me:

“If you can’t sulfate it, Minoxidil will not work. Peripherally sulfated Minoxidil cannot enter the cell.”

Also, in this 2020 letter from Ramos et al (full version here), a key quote:

“Increasing the activity of SULT1A1 can improve the efficacy of topical and low dose oral minoxidil for the treatment of AGA.”

Moreover, the following quote in last year’s important article from the AAD in regards to LDOM suggests some uncertainty via the use of the word “may”:

“It has been suggested that oral minoxidil may also be converted by liver and platelet sulfotransferase, thereby reaching a higher follicular accumulation.”

It would be interesting to know if beard growth with topical Minoxidil is also impacted by SULT1A1.

Boosting SULT1A1

In recent years, there have been some significant efforts made to develop products to boost the Sulfotransferase enzyme in order to improve the efficacy of Minoxidil. Leading the way is Dr. Andy Goren, who started a company called Applied Biology that created a Minoxidil booster product.

However, in June 2022, Applied Biology was acquired by Jupiter Wellness (part of US-based Safety Shot). Update: In February 2024, Safety Shot sold its Jupiter Wellness legacy assets to Elite Health Partners (US).

Luckily, while researching for this post, I came across Jupiter’s hair loss product page. Lo and behold, some interesting news on their Minoxidil booster topical product:

  • It has been clinically shown to increase the sulfotransferase enzymes needed for minoxidil to work by up to 7x over a two-week period. I assume this 2021 study pertains to those findings. Co-authors include the well known hair researchers Dr. Rodney Sinclair and Dr. Rachita Dhurat.
  • The product has already been licensed to Taisho for the Japanese market. Taisho is Japan’s leading seller of Minoxidil products. They expect to launch the product commercially in 2023.
  • It is also licensed to Cosmofix Technovation and Sanpellegrino Cosmetics, both from India.

Note that in the study that I listed in the first bullet point above, 75% of patients in the SULT1A1 group demonstrated a positive increase in hair growth; compared with only 33% of patients in the placebo group. However, the study limitations include its small sample and limited duration of follow up.