Follica and Histogen Updates

I was not planning to write a new post for several days, but there have been two important developments that are worth discussing now. I will update this post in more detail later if necessary.

Follica and Histogen Updates

  • First, Histogen has finally published a summary of its presentation at the recent Stem Cell Summit in Boston that I discussed before. I e-mailed the company and to my surprise, they sent me a pdf of their presentation that was made by CEO Dr. Gail Naughton.
  • Second, if you recall, a month ago I wrote a post on Follica and its surprising return from being taken as almost dead by many people. That post happened due to HLT forum member Xaser94’s great research, which he outlined in his now very popular thread. Several days ago, forum member “Noisette” made an interesting post in that same thread with a link to a 271-page June 2015 prospectus document from PureTech Health (majority owner of Follica).

There is a goldmine of information in there with some superb images. The main Follica section starts on page 101. Encouraging quote:

Through the administration of Follica’s procedure by a trained clinician and use of its at home ‘connected’ device (meaning it is coupled with a digital service such as a companion smart- phone application) the company seeks, in the near-term, to significantly improve the treatment expectations and satisfaction of hair loss patients by providing a more effective alternative to current FDA-approved drugs.

I also want to give kudos to Mike, who e-mailed me some useful information on this development. This is the same Mike that I discussed in my Follica post from a month ago. This time, I will only paste part of his e-mail:

This section stands out, and there are many standouts: 

Follica’s patented platform employs a technique called targeted cutaneous perturbation (or TCP) to stimulate the growth of new follicles, followed by treatment with: (i) select, approved drugs indicated to be synergistic in maximizing the quantity, quality and persistence of new hair, or in other cases (ii) new chemical entities that modulate pathways involved in the development of the hair follicle.

It’s the new chemical entities that interests me. Could there be a treatment and then an upgrade treatment further down the line? A partnership with another company perhaps? Maybe one that’s related to a certain Neal Walker?

In seems like in the past month, most of my posts have been heavily influenced by commentators on this blog, e-mailers, hair loss forum posters and even one hair loss chat participant on this site.

Interview and FAQ with Dr. Takashi Tsuji

In early April 2016, the renowned Dr. Takashi Tsuji from RIKEN (Japan) was yet again involved in groundbreaking new hair (and skin) related research.

Update: 2024 — Dr. Tsuji now has his own company called OrganTech.

Dr. Takashi Tsuji Interview

On April 3, I e-mailed him the following, hoping that he would grant my request for an interview:

Hello Dr. Tsuji,

I recently covered your two new partnerships (with Meiji Seika and with Adjuvant Cosmetics) as well as your paper regarding bioengineered skin.

Is there any way you would be willing to do an interview with me for my blog?

Admin

His almost immediate response:

Dear Admin,

Thank you so much for your interests to our study.

We collaborate with Adjuvant cosmetics to study on the development of a novel hair promoting agents by using our developed screening system. The collaboration with Meiji Seika pharma and other companies plan to develop a novel bioengineered skin in vitro with skin appendages including hair follicle and sebaceous gland. This bio-skin will contribute the developments to cosmetics, quasi drugs and anti-allergic agents.

Unfortunately, I would like to answer only by e-mail.

Thank you for your contact.

Sincerely,

Takashi

I was surprised that he replied (and mentioned both the companies that I mentioned in my e-mail), since he must have been extremely busy being bombarded with interview requests from around the world so soon after his latest groundbreaking paper was published. It also seemed like the ending of his above e-mail response implied that he would be willing to grant me an e-mail interview.

So I sent him a list of detailed questions. Unfortunately this time, no luck:-( Dr. Tsuji sent me a generic reply that he was sending to all journalists. I do not blame him at all of course. Below is his reply and attached FAQ file attachment that he sends to journalists.

His second response:

Dear Admin,

Thank you for your contact regarding our recent work.

I am grateful that you have great interests to our recent bioengineered skin study. Unfortunately, I enclosed FAQ, which was asked from many reporters in world-wide. I also enclosed the figure, which demonstrated successful transplantation of the bioengineered 3D integumentary system derived from GFP-expressed iPS cells. Green fluorescence indicates the bioengineered skin including iPS-derived hair shafts.

Regards,

Takashi

FAQ Document

Here is the FAQ document from Dr. Takashi Tsuji.

Lots of interesting information in there and hopefully you can download it ok. Among the highlights:

  • Dr. Takashi Tsuji and his team’s latest study successfully demonstrated the proof-of-concept to induce bioengineered skin formation from iPS cells in mice.
  • The transplanted whole skin could engraft and function for over 70 days in recipient mice. In addition, the resultant hair follicles repeated their hair cycles just like natural hair.
  • The team plans to realize this same skin and hair regeneration technology in humans within 10 years.

The image below that he included is of “bioengineered skin with iPS-derived hair shafts”:

Dr. Takashi Tsuji: Bioengineered skin, including iPS-derived hair shafts.
Dr. Takashi Tsuji: Bioengineered skin, including iPS-derived hair shafts.