Macrophages and Hair Follicle Stem Cells

Update: Seems like the positive impact of macrophages on hair growth was already known in 2007. That study from Japan was titled “Macrophages boost hair growth.” Thanks to commenter “spain”.

I heard about all of the above developments right around when they first occurred. Nevertheless, I was still not particularly hopeful of anything significant happening in Spain when it comes to hair loss research related breakthroughs. Most of the widely respected hair loss research scientists in the world seem to reside in the US, UK, Germany, Japan and several other parts of Northern Europe and East Asia.

Macrophages and the Activation of Hair Follicle Stem Cells

However, two days ago, Spanish scientists (from the previously mentioned cancer research institute CNIO) led by Dr. Mirna Perez-Moreno and Dr. Donatello Castellana published a groundbreaking hair loss research related paper in the PLOS Biology journal titled “Macrophages contribute to the cyclic activation of adult hair follicle stem cells.” It should be noted that Dr. Moreno has previously worked at noted hair loss researcher Elaine Fuchs’ laboratory as a postdoctoral fellow. Further lending credibility to this paper is a third co-author and well known hair loss researcher by the name of Dr. Ralf Paus.

For the average layperson (including myself), the above publication is difficult to digest in its entirety. At least if one does not want to spend hours reading it and going back and forth with google dictionary. So below are links to articles with easier to understand summaries:

Article 1: From the sometimes great, usually trashy dailymail.

Article 2: From EurekAlert.

Article 3: From the Spanish elpais (use the “Translate to English” option in the Chrome browser).

The main findings:

  1. Macrophages (a type of white blood cell) can activate adult hair follicle stem cells.
  2. Mice started to regrow hair when they were given anti-inflammatory drugs. It seems like this whole year in hair loss research can largely be summed up by the words “inflammation” and “anti-inflammatory”.
  3.  Macrophages secrete a number of growth factors including a class of proteins called Wnt. You can do a search on this blog for Wnt, Wnt7b and Wnt/Beta-Catenin to learn more about Wnt proteins and corresponding pathways.

As usual the study was carried out in mice and not humans. However, I think that it is now only a matter of a short time before we see an increasing number of trials in humans. As I have mentioned many times, this will probably happen faster in Asia than in other regions due to regulatory reasons.

11 thoughts on “Macrophages and Hair Follicle Stem Cells”

  1. All those people that’s still think baldness and immune attacks are not related will be in for a surprise. I really think there is a significant correlation between body’s response to most likely an faulty read of the follicle dna perhaps.

  2. Many thanks for all the posts, Admin.

    I wish you the very best for 2015. Happy new year. We all expect a breaktrough for the hair loss research in the coming year !

    My very best regards.


  3. William thanks for the wishes and great to have readers like you.

    Spain, thanks! I updated the post. Have not had time to compare the 2007 study in its entirety with this one, assuming the former is fully available.

  4. What a shame! I was like finally a good news and no, it isn’t! Why do they talk about macrophage like it was a new breakthrough ? I don’t get it!! Anyway, Happy new year to all of you! Hope this year we’re going to get good news for a cure, we never know!

    1. I don’t know Englishman, I thought it meant something before the comment of “Spain”. let’s find out why they are going to say about this suppose breakthrough later on the media! (Sorry for my English)

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