Category Archives: Michael Rendl

Dr. Michael Rendl — Mesenchymal Control of Hair Follicle Formulation, Growth and Regeneration

On this blog, I have in the past discussed various dermatological associations and non-profits, including several important ones in the United States such as the American Academy of Dermatology (AAD) and Advancing Innovation in Dermatology (AID).  A third one called the Society for Investigative Dermatology (SID) recently had its 75th annual meeting on May 11th, 2016.

On SID’s youtube channel, you can find a number of the video presentations from this meeting, including a few that discuss hair in at least part of the presentation.  On SID’s website they have a summary list of presentations that includes quite a few involving hair, but none of those videos seem to be available as yet.  Hopefully they will make more of them publicly available soon assuming they videotaped all the presentations.

For now, the most relevant video when it comes to our cause is a presentation by Dr. Michael Rendl that I have embedded below.  On this blog, I have discussed Dr. Rendl’s work several times in the past, including in this post about his Rendl lab.  The below video is highly interesting, especially when it comes to the crucial dermal papilla cell and its induction of hair growth.  I did not realize how complicated this process is and how researchers still have so many uncertainties about the various signals, transcription factors, pathways and processes that lead to the dermal papilla inducing hair growth.

The parts on gene expression, RNA deep-sequencing and CRISPR-mediated genome editing are also very interesting, especially since CRISPR has been in the news so much in the past year (and it now seems inevitable that adult humans will be able to have their genes edited in the future).  A lot of the content is very technical and way above my head.

Kudos to Dr. Rendl for creating the hair-GEL (gene expression library) website for sharing this crucial information with everyone for free.

It is too bad that Dr. Rendl is totally bald and seems to be very comfortable with that look.  I would have preferred it if he had a combover or hairpiece that would suggest much more of a personal interest in this subject matter (as we have seen with Dr. Angela Christiano, who wears a wig fit for a queen).

 

Brief Items of Interest, November 2015

Hair loss news first:

Update: Samumed released this optimistic sounding PR statement a day after I wrote this post.

“Hellouser” in Miami thread.

— I discussed the important work of the Rendl Lab and Dr. Michael Rendl a few months ago.  Several weeks ago, it was announced that Dr. Rendl’s team have created an online database that will allow researchers to study the interactions between hair follicles, stem cells and their surrounding environment.  This database is called Hair-GEL (gene expression library).  It is worth playing around with this database even if like myself you do not understand or recognize the names of most of the relevant genes.  This sort of open source project is extremely encouraging.

— Yet one more positive report on Adenosine and hair.  Make sure to read my post on Shiseido and Adenosine from last year.

Christopher1 on Hairsite has been testing out topical Tofacitinib to tackle his hair loss (as well as his vitiligo per another of his posts). Worth bookmarking that thread, but do not emulate him!  Too risky in my opinion.

Dr. Joseph Greco published a new chapter on PRP and stem cells in a textbook

— Joe Tillman (aka “Jotronic”) has initiated an excellent project to offer free repair work to those who have been damaged by bad hair transplants.

3D Printing of Hair.

— Update on the 3D printed comb to treat hair loss from Technion University in Israel.  They have a link to a dumb video about their project that almost made me ignore this update….but it made sense to have this here right below the 3D printing of hair link.

Interesting video of what goes on at Dr. Alan Bauman’s clinic during initial consultation and examination.  Funny that the hirsute patient in the video seems to think that he has something wrong with his hair… although when I first started losing my hair, I was probably the only person in the world who thought that there was a problem with my hair:-)

And now on to medical items of interest:

— A great new face transplant success story about ex-firefighter Patrick Hardison.  He also got new hair and I wonder if it will grow as long as the stellar hair that the dead donor had?  The most interesting quote in the article is the following:

“Of the roughly 30 patients who have received partial or full face transplants, Rodriguez said some three to five patients have died after rejection.”

I was unaware of this fact and had assumed that nobody ever died from these procedures.  I thought the worst case scenario was that the new face would be rejected (without any death) or that in the long run someone would have a higher chance of getting cancer and other medical problems due to taking the anti-rejection/ immunosuppressive medications for years.  Hopefully these death rates become zero as scientists gain more knowledge with each new patient.  And perhaps in the future it might also no longer be necessary to take immunosuppressants.

The heart is just a pump.  My father recently needed to get two stents put into an artery after a heart attack, so this subject is especially interesting to me.

— Interesting CRISPR related articles are now being published on an almost daily basis and it is hard for me to only pick 1 or 2 every month.  The best one was published today and includes interviews with some of the world’s leading geneticists.  The New Yorker had a good one this week titled “Gene Hackers“.  Editas Medicine will commence CRISPR gene editing trials to treat a rare form of blindness in 2017.

— And finally, a new TED video from CRISPR co-pioneer Jennifer Doudna: