Category Archives: PRP

Greco Medical Publishes PRP Study Findings

Update: Based on a reader’s comment to this post regarding frequency of treatment, I contacted Dr. Greco and he said that he tries to get his hair transplant patients to get PRP injections once a year after the transplant. He uses a more purified version of PRP called CRP, and the details of that can be found on his website.

Greco Medical has been a long-time proponent of using platelet-rich plasma (PRP) during hair restoration procedures. In September 2014, The Journal of Dermatologic Surgery in the US published the largest ever PRP study related to hair. Dr. Joseph Greco was one of the four authors of this study.

I am impressed by some of the detailed content on there and they had both male (42) and female (22) participants. It does seem a bit limiting in that only “two independent evaluators” decided on the success or failure of the end results. The two before and after photos in there (female on page 1015, and male on page 1016) are impressive and in all likelihood among the best-case results.

According to the two evaluators, the overall proportion of patients seeing a clinically significant improvement at 6 months post PRP treatment was 40.6% and 54.7%, respectively.

As with low-level laser therapy (LLLT), I have also always been very skeptical about PRP. My skepticism for both has subsided in the past year or two as more supportive studies have come out and as more surgeons have started offering both LLLT and PRP. However, I am still not convinced that either of these technologies offers more than a limited improvement in hair quality and thickness for the average person.

It also does not help when most of these study authors include hair transplant surgeons who are already big proponents of PRP and/or LLLT in their practices. It would be far more believable if researchers, universities and companies that are entirely financially disassociated with PRP published such studies.

ACell and PRP Treatment for Hair Loss

Over the past decade, ACell and autologous platelet-rich plasma (PRP) combination treatment has become widely utilized. In large part, this is due to the wound healing and regenerative properties of both products. There is nevertheless significant debate about the extent of efficacy of both Acell and PRP.

ACell Plus PRP Combination to Grow Hair

ACell MatriStem Powder
ACell MatriStem ECM Powder.

The effectiveness of PRP treatments upon hair regrowth is especially controversial. In my next post I will discuss recent studies on this as well as my thoughts about this subject matter.

Despite these uncertainties, an ever increasing number of hair transplant surgeons now offer PRP. This is often done in combination with ACell (see the manufacturer’s website for product details). Some offer PRP to improve and speed up hair transplant results. Some also offer these injections in small lunch hour sessions in order to increase existing hair density and quality.

ACell MatriStem

Acell MatriStem UBM™ is often referred to as “porcine urinary bladder matrix.” It is derived from pig bladder cells, and has proven to be helpful in wound healing.

Wound healing and hair follicle regeneration have a number of similarities and are often researched together. ACell is a type of extracellular matrix (ECM) system and comes in powder form.

It was overhyped in the media for a few years due to its ability to regrow Lee Spievack’s finger in 2005. It turns out that this was junk science, and not some kind of “pixie dust” magic powder. A 2010 update reached the same conclusion. Sometimes, the human body can regrow a cut or damaged fingertip without the need for any external assistance.

Declining Interest

In recent years, there has been declining interest in the use of ACell and other extracellular matrix products to treat hair loss. Nevertheless, some surgeons still swear by this combination treatment for hair regrowth and regeneration.

Dr. Samuel Lam’s PRP and ACell video.