KX-826 (Pyrilutamide) Cosmetic Launched

Price Drop Alert — The new Kintor Green Version with 0.5% KX-826 plus various natural ingredients is currently on sale for almost 70% off (after including the coupon option below the discounted price). So it will cost just $28 after taxes. Very strange, as the other two products are not similarly discounted.


See my regularly updated post on China-based Kintor Pharmaceutical’s clinical trials for their two main topical androgen receptor targeting products. Both may come out in the next few years if Phase 3 trials are successful.

Meanwhile, the company launched a KX-826 (Pyrilutamide) based cosmetic product in 2024 after receiving International Nomenclature Cosmetic Ingredient (INCI) approval.

Update: June 2025

Kintor now sells three versions of its KX-826 spray for hair loss.

  • The purple version with 0.9% KX-826.
  • The blue version with 0.5% KX-826.
  • The new green version with 0.5% KX-826. It comes with a plant-based extract essence that promotes scalp blood circulation and nutrition to hair follicles. The full list of natural ingredients can be seen here.
Kintor KX-826 Spray
The Kintor KX-826 spray for hair loss now comes in three versions.

July 26, 2024

KX-826 Hair Growth Spray Launched

The blue version is priced at $69 for a 1-month supply (plus a 5% off coupon) and contains 0.5% KX-826 (pyrilutamide). Update: The enhanced 0.9% KX-826 purple version is also on Amazon now. Both are made by Koshine Biomedica (China) in Hong Kong.

Each product comes as a topical spray. There are no reviews or product ratings at the time of writing this post. The product description mentions that it is a dihydrotestosterone (DHT) blocker, and reduces sebum excretion and scalp oiliness.

Note that the actual androgen receptor antagonist KX-826 is still in Phase 3 clinical trials in the US and China. The cosmetic product (image below) is a way for the company to release a topical product faster.

Kintor KX-826 Cosmetic
Kintor Pharmaceutical (China)’s KX-826 Cosmetic Androgen Receptor Antagonist. Made by Koshine Biomedica (China).

Also of interest, one of the images on Amazon implies more rapid hair growth from this spray product in comparison to FDA approved Minoxidil:

KX-826 versus Minoxidil
KX-826 versus Minoxidil hair growth comparison.

Usage Instructions

The instructions on using this KX-826 spray are as follows:

  1. Open the outer packaging and insert the spray head onto the bottle.
  2. Find your area of hair loss, use your fingers to expose the scalp, and then apply th30e anti-hair loss liquid spray.
  3. Use once in the morning and once in the evening. For a total of 6-8 sprays each time, which equates to about 1ml.
  4. Massage the scalp for about 3 minutes after the spray has been applied.

Note: Only meant to be used when your scalp and hair are both dry.

118 thoughts on “KX-826 (Pyrilutamide) Cosmetic Launched”

  1. I’ve heard of this in the past. Is it better than rogaine? Is it worse on sides? I procrastinated 10 years to late on treatment and am a norwood 5 lol.

    Would kill to be a 3v at this point in my life at 33, wondering if this is something i should try or i should try rogaine.

    When I get back home in a week I want to begin fighting, even have a derm appointment, going to try fin maybe as I’m a diffuse thinner and its getting my sides and back.

  2. Hello everyone, what is your educated guess on when hair regeneration will become commercially available? Like how many years away? Thank you

    1. There’s a few that could fit the bill in certain ways.

      The only for sure release date is with Mallia Therapeutics and their cosmetic that claims to help regeneration and that should be released this year.

      Key ones assuming they go well:

      PP405 is probably a good middle ground for regeneration but that’s probably 3-4 years out.

      Then OrganTech which also is probably 4-5 years out. But that’s assuming no setbacks.

      1. Thank you Falcon for replying. When do you think the actual cloning procedure will become commercially available? Like the one that Stemson worked on but failed. Thanks.

        1. i think its amazing, that we have so many companies, which actually do clinical trails.
          that makes me believe, that the next 10 years something better than fin could enter the market.

          still – the real haircloning is faaar away in my opinion. I think tsuji and co will never do trials on humans. i would wait for the next generations of researchers. maybe in 70 to 100 years from now even tho its to late for us.

  3. Have been using the KX-826 1% from Amazon for the past 3 months with no effect at all. The same hair loss as before using it. Unfortunately:(

  4. Hi Admin, anything to report from using the green bottle? Any headache or heart rate increase? Any shedding or anything to report? Thanks.

    1. No nothing to report in two days.

      The spray does leave the scalp slightly damp for a while even after rubbing it in. Reminds me of the past when I used topical and later foam Rogaine.

      After rubbing in the KX-826 spray into my scalp (as instructed), I have even scratched my eyes by mistake or touched objects at my desk. The fingers get slightly sticky each time you rub the spray in.

      1. Hi admin,
        What is your educated guess on when hair regeneration will become commercially available? Like how many years away?
        Thanks,
        Victoria

          1. Could you please tell me your personal guess? Like in terms of years, I know you don’t know for sure but please tell me your estimate. As you read a lot of literature on this topic.

      2. I recently purchased the new herbal infused Koshine product, after you wrote about it. The price is hard to beat. However, I find it to be stickier than the standard .5% or .9% versions. It seems like it has more propylene glycol, or maybe it’s just the herbal residues. I’ve been using .5% since October and .9% since December. The herb-less solutions absorb quicker. I’m happy with the results and I think it’s a good product. With twice daily use, I’ve had modest regrowth on my vertex (the diameter of my bald spot is smaller) and even some regrowth at my temples, which, though insignificant, is staying.

        The biggest side effect I’ve noticed is the drying effect of the alcohol. It really dries out my scalp. I’ve also experienced puffy, sensitive nipples that tend to chafe while exercising. It’s *probably* a side effect of the KX-826. I switched to using the .5% solution in the morning and the .9% solution in the evening, and it seems to have alleviated the problem.

        1. Thanks for the great feedback Al! Did the .9% in December give you any clear benefits in comparison to the 0.5% in October?

          1. It’s hard to tell, as I hadn’t been on the .5% long enough to plateau. I figured “stronger is better.” I had a strong initial response, which included the minimal-but-gratifying regrowth at my temples, but switching to .9% didn’t make a dramatic difference. My totally unscientific feeling is that I experience less shedding with the .9%, and that my hair growth cycle is longer. I hope it works for you. It seems like it would be a promising adjunct to dutasteride or finasteride, at either concentration.

  5. Hello everyone,

    I am lost again, too much news and too many players around, so once again I’d like to ask you who’s in pole position. Is Pelage still that imminent miracle we all await?

      1. Which one? I think we currently take the same meds (oral Dut and min)?! I am 100% starting this month. Either the 0.9% or the foam or ‘max’ version coming out by the end of the month.

        1. Yes I currently take oral Dut twice a week and oral Min daily.

          Was thinking of trying the KX-826 0.9%, but will now try the Green 0.5% first as it is so cheap (and I like all the additional natural ingredients in case they can reduce my scalp itching and inflammation).

          1. Update: Started the 0.5% KX-826 green bottle today. It does not say exactly how many sprays you should use per area of the scalp…I think I used 5 sprays across around 2/3 of my scalp. The spray does not go all over the place and is liquid like once on the scalp, which you have to rub in with your fingers.

            The natural ingredients in the green one are as follows in case anyone missed this in the post:

            https://www.koshinemall.com/cdn/shop/files/06_e2cae693-54ec-4713-9af8-3087ad7d06aa.jpg?v=1747211933&width=1920

            I hope the Hong Kong manufacturer is infusing these into the spray in a correct manner.

            I am not expecting much at all. But even less itching and inflammation would make me like the product.

    1. All three of the products are currently 10-15% off on Amazon if you select the apply coupon box. And two of them already have a reduced price (see the strikethrough bar across the smaller font list price).

        1. No, but the green one is still only $30. Not sure why the are pricing it so much lower than the blue one, since both have 0.5% KX-826.

  6. I got crazy hair fall after like 3 months of using kintor 1% and i stopped. Please advise me can i go ahead of using or should i stop?

    1. The same thing happens on fin, its called the shedding phase and means its working and that new hair will come back thicker etc. I wouldn’t stop, or the 3 months work you put in is pointless. Keep going with it for at least 6 months to properly gauge the results. Best of luck.

    2. I’m no doc, but it’s usually a very good sign. I had major shedding 3 months later after a dosage adjustment on oral Min/topical Fin. Parts of scalp started showing under top light, etc. It’s a really sh*t experience, but thankfully after some time hair came back thicker.

      1. That’s what’s happening to me, SummyKin. My hair has become significantly smaller even though I’m taking oral dutasteride and min daily. At this point, I think I could recover with the Shiseido technique, but it seems complicated to treat if you’re not from Japan…

        1. I’m not familiar with the “Shiseido technique”, but I would try and stick it out a bit longer. As I stated, I’m no doc, but you might be surprised how quickly your hair bounces back once the initial shedding finally stops. I went through a massive shedding stage – it was disturbing to say the least. Great clumps of hair in the comb every morning for almost a month…then eventually back to normal. Hope this helps.

  7. An update to one of the Amazon reviews is interesting:

    “After 3 weeks of use I can report it stopped my shedding, but I also got very bad side effects: head ache, dizziness and ED. I am fully aware that all medications can have a side effect and thus definitely went systemic.”

    3 reviews in there so far:

    https://amzn.to/3ZiqFNV

    1. The review seems strange since the active substance stops DHT binding to the follicle and does not stop testtosrone being convrted to DHT. Since there is no change in DHT how can one get sides worse than fin?

  8. I think Kintor’s financial situation is terrible that they had to sell 1% concentration before clinical trial. Although 1% concentration is still not enough and more than 2% should be used to be effective.

  9. Another BS diluted cosmaceutical to add to your heavy hairloss “med stack” that will do nothing more than hold onto thinning, wispy hair. Marketing to desperation.

  10. Coegin Pharma is a Swedish biotechnology company with innovations in dermatological cosmetics for hair growth and skin pigmentation, as well as leading drug candidates for the treatment of heart attacks and leukemia. Coegin plans to launch its first line of hair growth products in 2025, followed by a skin pigmentation product in 2026.
    The company received the INCI name, which is crucial to be able to sell beauty products globally, and a memorandum of understanding was signed with the Chinese company Zhejiang Sukean Pharmaceutical. shares

    1. It is not helpful to place unrelated news/stories – please send link to admin to create a new h th read if it’s substantial.

  11. I don’t know what you think about GT20029, but I am very skeptical about the results of the phase 2 clinical trial of GT20029. In the 0.5% group, after 12 weeks (less than 3 months), the placebo group had an increase of 10.11 hairs per square centimeter! Can someone explain to me what is this placebo that causes an increase of 10 hairs per square centimeter in less than 3 months?!!!! I can’t believe it with any logic. I believe that the placebo group participants cheated and used fin or min. In the 1% group, the result of the placebo seems reasonable, but the result of the GT20029 group with a concentration of 1% twice a week does not seem reasonable to me, which caused the growth of 11.94 hairs per square centimeter by using only twice a week and less than 3 months. Yes, and I am sure that the participants of this group also cheated and used fin or min.

    1. I agree with you bill. What do you think about the twice weekly protocol for GT20029? I think that twice a week reduces the effectiveness of the drug and you should use a concentration of 1% daily.

      1. In the phase 1 clinical trial, the maximum concentration they tested was 2%, and interestingly, the average maximum serum concentration of the drug was 0.015 ng/ml. That is, the systemic absorption of the drug was severely limited. I also believe that the twice-a-week protocol is a poor protocol and the drug should be used daily. Also, due to the limited systemic absorption of the drug, they should have tested higher concentrations. Unfortunately, kintor didn’t learn from the mistake he made with kx826 and made the same mistake again with GT20029. Instead of using the maximum safe dose, they use the minimum safe dose, and this increases the probability of clinical trial failure.

  12. @Admin
    Kintor might release the 1% dosage before finishing the trials as well. I have found the item on the website already.

      1. You will find postings on Reddit already. We have contacted Koshinemall. They were saying release of 1% solution within the next 3 Month.

    1. Thanks for the post Lorence, but Mr. Admin, could we make this its own thread? It’s clearly been a new story that is noticed, but it would be easier to follow as its own post??

  13. Unfortunately, Kintor carelessly destroyed the pyrilotamide. I request you, the readers, to visit the pubchem website and view the chemical structure of enzalutamide and pyrilutamide. The two drugs are surprisingly similar, and it is quite clear that pirlotamide is made from enzalutamide. Question? So why didn’t pirlotamide work? Answer: The dosage is ridiculously low. I’ve tried up to 3% (30mg) with great results so far (no side effects) and I’m also planning to try higher concentrations to see how my body reacts to it. Unfortunately, Kintor does not achieve the desired result even with a concentration of 1%, and higher concentrations should be tried. If enzalutamide works as an antiandrogen, pyrillutamide should work as well. I hope more people like me try higher doses based on individual tolerance. Unfortunately I predict we will have the same problem later with GT20029.

    1. it could be that they tried lower doses because they were worried about possible side effects causing adverse events and causing the trial to fail.

      1. Kintor tested doses of 3 mg, 12 mg, and 48 mg in a phase 1 clinical trial. Even at the dose of 48 mg (4.8%), there were few side effects. I laugh when I compare the dose of pyri (5mg) with the dose of ru58841 (50mg). It is true that pyri is stronger than ru58841 but not 10 times!! In my experience with pyri, the minimum dose is 25 mg (2.5%).

        1. Which means that the current 0,5% (KX826) will not be absorbed systemic? I am sorry for asking but I cannot find the studies etc and I am concerned about any systemic exposure

          1. According to the phase 1 clinical trial, the systemic absorption of 3 mg (0.3%) was zero, but the systemic absorption of 12 mg (1.2%) was 0.3 ng/ml, which is practically safe. It can be assumed that a dose of 5 mg (0.5%) has a systemic absorption close to zero.

        2. That’s why I’m sticking to RU58841. It’s much cheaper per gram and I can use a much higher percentage. I’m using 3ml of 7% mixed fresh every application.

    2. This is an intriguing post, Bill. How can we follow your progress? Do you have pictures showing your very positive results? Good luck!!

      1. John, it’s been about 2 and a half months since I started using it. I will share my before and after pictures when I reach 6 months.

      1. dark prince, I order pyri powder from China. I sent the powder to the lab before using it to make sure they didn’t sell me another substance instead of pyri!

  14. Does anyone know if this goes systemic? Admin any comment? I cannot find the study and if this had an affect on hormone (testosterone) levels or if it was found on the serum of the participants. I guess a doc must advice since its a new drug. I really hope it is sides free.

    1. I was ordering grey market from a popular supplier in Europe. It gave me crazy insomnia and racing heart.

      I’m not sure if anyone else experienced that

  15. Unfortunately, based off product images listing the ingredients list, this version sold on Amazon has propylene glycol. PG causes skin irritation for a lot of people, as PG allergy is common. In kintor’s panel literature for KX-826, they talked about the downfalls of competing hair loss treatments including the use of PG and the ensuing irritation it causes. Yet they’ve licensed a distributor that chose to use PG in the solution, making this product unusable for many.

    Hopefully, they’ll make a PG free version soon.

    1. hello, please any website to purchase this topical i want to try it out “pterostilbene and nicotinamide” greyhair reverse . BR

  16. Crazy they can’t come up with one product that works… instead we have to have a 7 layer stacked burger of products that will probably (eventually) do something negative to us when combined and used long term.

  17. I ordered 3 months worth. Seems like a complimentary approach to the main stack. I’ll let you guys know if I see anything decent.

  18. Hi Admin. when i click on the link in your write up for the product for sale on amazon. It send me to a blue hair dye. i cannot seem to find this product on there. any help is appreciated.
    Thanks
    D

  19. @admin

    Can you elaborate on this

    “The cosmetic product (image below) is a way for the company to release a topical product faster.”

    What exactly allowed then to release it faster? Just labelling it cosmetic product? Or something else?

    Thanks

    1. Mg89 puts it perfectly. What is this stuff? Same strength? If it’s different, how so? This drug doesn’t appear to be very effective in any case and if this cosmetic product is watered down it’s almost certainly a colossal waste of your money.

  20. Is the cosmetic identical to what is being tested in Phase III, but they just can’t make the claims yet?

    1. Thanks Daniel, I got 4 e-mails about it (and also posted a comment about it earlier under an older “natural cures” post)!

      Lets see if it ever works in humans.

    2. The story is clickbait.

      “The deoxyribose gel was so effective, researchers found it worked just as well as minoxidil, a topical treatment for hair loss commonly known by the brand name Rogaine.”

      ***as well as minoxidil***

      1. Any side effects so far? When did you begin kintors product? Notice anything different? Less oiliness etc?

        1. Dear Tom, I have not used it yet, but I will buy this product at the first opportunity when it is available in my country.

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