The Ultimate Natural DHT Blocker

Most people would prefer taking a natural DHT blocker for hair growth rather than Finasteride or Dutasteride. However, the latter two synthetic drugs are far more effective in regrowing hair, albeit with the possibility of worse side effects.

Natural DHT Blocker.
DHT Blocker with Saw Palmetto and Pygeum.

Nevertheless, natural dihydrotestosterone (DHT) blockers can significantly reduce high scalp dihydrotestosterone levels, and at least modestly help with hair growth. In this post, I will outline the most famous and effective natural DHT inhibitors to combat androgenetic alopecia. Some of these work by blocking 5-alpha-reductase enzyme activity, which converts testosterone to the DHT hormone.

I also ask you to submit your suggestions for other lesser known natural products that have scientific backing in reducing DHT levels. For example, a number of studies from Asia have found sea or marine based algae (such as Ecklonia cava) and other plants to be effective at reducing DHT levels via inhibition of 5α-reductase activity.

The Best Natural DHT Blockers

Propidren DHT Blocker
A popular oral DHT blocker containing saw palmetto, nettle extract and pygeum.

A number of natural herbs and plants have been proven to reduce DHT significantly. The extracts of some of these natural “medicines” seem to regularly appear in hair loss products such as the one on the left.

Below, I outline some natural DHT blocking ingredients that I have seen over and over again in various natural hair loss products that do not require a prescription. Many contain added ingredients to benefit hair growth, especially B-vitamins such as biotin and niacin.

  1. Saw Palmetto Plant.
    Saw Palmetto Plant.

    Saw Palmetto (Serenoa repens). By far the most popular natural DHT blocker in the world. Saw palmetto extract is derived from the fruit of a specific variety of palm tree. A famous study found that 38% of people with male pattern hair loss who took saw palmetto experienced an increase in hair growth; versus 68% of those on Finasteride growing hair. The key ingredient in saw palmetto that is thought to counter DHT production is beta-sitosterol. If you are taking an oral saw palmetto supplement, typical daily dosages range from 160 mg to 320 mg. Note that even natural supplements can cause side effects in some people, so please consult a dermatologist before trying these products.

  2. Pygeum. A lesser known product derived from pygeum bark of an african plum tree. Pygeum africanum can reduce prostate size and urinary tract problems per one summary of various clinical trials. Most products that reduce the size of the prostate gland enlargement typically do so via reducing DHT levels, either directly or indirectly via 5α-Reductase.
  3. Nettle Plant Extract.
    Stinging Nettle (Urtica Dioica).

    Stinging nettle (Urtica dioica) or nettle root extract. A number of studies have found that this alternative treatment reduces benign prostatic hyperplasia (BPH), aka enlarged prostates.

  4. Pumpkin seed oil (PSO). A surprising ingredient that has been been shown to block the action of 5-alpha reductase and has antiandrogenic properties. Sometimes available as part of a DHT blocker oil.

Besides the earlier mentioned Propidren, another competing product is Folliform for men and women. Sometimes this product is cheaper at Walmart. Other well known natural oral DHT blocker brands include Advanced Trichology, DrFormulas, NuHair and Shen Min.

Your Ingredient Suggestions

What other natural products do you like that reduce DHT significantly? If you can find a number of scientific studies that support your suggestion, I will take your comment seriously. Several manufacturers of bestselling hair loss shampoos and supplements have asked me over the years to make ingredient recommendations to treat hair loss. I think they are serious about adding new natural products into their product recipe if there is sufficient evidence and reader interest in doing so.

Among other products that block DHT include specific varieties of:

  • Seaweed, sea vegetables and alga (algae).
  • Essential oils such as tea tree and rosemary.
  • Mushrooms.
  • Seeds such as flax and sesame.
Green Tea DHT Blocker.
Green Tea (EGCG) DHT Blocker.

Also thought to reduce DHT on the scalp include lycopene, soy, tea tree oil, green tea (via Epigallocatechin gallate aka EGCG), sterols, turmeric, ketoconazole and more. You will find most of the products mentioned in this section as ingredients in various shampoos and conditioners. Wikipedia has a lengthy list of 5α-reductase inhibitors.

Even drinking certain beverages such as black tea and lycopene rich juices (tomatoes, watermelons, carrots) is thought to modestly reduce DHT levels. Some vitamins and minerals can also naturally reduce DHT, albeit modestly. It should be noted that caffeine is unlikely to reduce dihydrotestosterone levels.

Topical DHT Blockers and Inhibitors

Most natural DHT blockers come in pill, tablet or capsule form and are taken orally or internally. However, recently, I have noticed some popular topical DHT blockers and inhibitors in solution or serum formats. Some even come in spray cans or bottles. Most contain saw palmetto as the key ingredient. I am not sure how effective these topical products are at blocking DHT, but some have numerous positive reviews and ratings. Key ingredient delivery is perhaps easier in comparison to topical finasteride.

DHT Blocker Ingredients.
DHT Blocker Ingredients.

One popular topical product on Amazon is Propidren serum by Hairgenics. Among its DHT blocking ingredients shown on the right include:

  • Saw palmetto fruit berry.
  • Beta-Sitosterol.
  • Horsetail extract.
  • Nettle extract.
  • Fo-Ti root.
  • Pygeum bark powder.
  • Green tea extract.

Another highly rated product is an organic saw palmetto based serum that also contains an assortment of essential oils. The latter includes: pumpkin seed oil; moringa oil; baobab oil; blackberry seed oil; flaxseed oil; rosemary oil; peppermint essential oil; cedarwood essential oil; and oregano oil. There is some evidence that essential oils can help your hair become thicker.

Destroying Androgen Receptors on the Scalp

Recently, a reader and hair loss sufferer named “James K” sent me a very interesting e-mail pertaining to destroying androgen receptors. I have pasted most of his e-mail content towards the bottom of this post. Note that the androgen receptor is also known as NR3C4. Other options include looking into androgen receptor antagonists or androgen receptor silencing.

Destroying Androgen Receptors to Stop Hair Loss

Scientists know that male pattern hair loss (androgenetic alopecia) is caused by two factors that both need to be true:

  1. The presence of high levels of dihydrotestosterone (DHT — a derivative of testosterone) in the bloodstream and scalp. Note that 5-alpha reductase enzyme activity is what converts testosterone to dihydrotestosterone.
  2. The presence of a high level of androgen receptors on the scalp. Balding is a direct result of DHT binding to these receptors and then miniaturizing hair follicles. Many people can have high levels of DHT, but lack the androgen receptor (AR) gene. In those cases, they will not go bald. Finasteride drastically reduces DHT from binding to 5α-receptors, resulting in increased hair growth for many people.

Follicle sensitivity to the damaging effects of androgens varies by person. The number of androgen receptors on a scalp’s dermal papilla cells also varies from individual to individual. Research seems to suggest that genetic predisposition to AGA is polygenic in nature and there is no individual gene that is responsible for male or female pattern hair loss. Note that some sources seem to term “androgen receptors” as “DHT receptors”.

On a related note, eunuchs who are castrated never suffer from male pattern baldness. Their DHT levels are negligible for their whole lives. Also of interest is the androgen insensitivity syndrome intersex condition. I bet some blog readers wish they had such a problem.

Going back to “James K”, his main question pertained to why scientists have not done more research into destroying the androgen receptors on the scalp?

Or somehow destroying the androgen receptor gene? While we await CRISPR based gene modification, other techniques such as NdAgo have so far been a bust or overhyped.

How to Destroy Androgen Receptors?

I will quote “James K” in this section:

“I think that a cure would be to destroy these androgen receptors on the scalp, thereby making their sensitivity to androgens irrelevant. Androgen receptors are heat-liable and can be destroyed by trypsin.

Trypsin is possibly safe for topical application, but has the side effects of pain and burning. From a study on rats, trypsin causes hair cells to die and regrow slower, as it changed their gene expression.

Perhaps a safer/weaker version of this can be developed for hair loss? What do you think?”

My Thoughts

I am surprised that there is not much more research on this available online. Is it possible to destroy androgen receptors on the scalp without killing the actual hair follicles? Or is this nonsensical, with the only future solution being a genetic one? i.e., deactivating the AR gene responsible for hair loss?

Update: Someone sent me a link to research on silencing the androgen receptor.