Pola Chemical Industries: Patent for Producing Human Hair Follicle Organoids
In March 2025, a Japan-based company called Pola Chemical Industries was granted a Japanese patent for producing human hair follicle organoids. It was first filed in 2023. Pola Chemical is part of the much larger Pola Orbis Holdings Group, which focuses on developing new skincare and cosmetic products.
The new patent pertains to a novel technique for producing human hair follicle organoids. It comprises co-culturing epithelial cells, mesenchymal cells and pluripotent stem cells in specific ratios relative to each other.
Note that a number of other companies and researchers have been working on creating pigmented hair follicle organoids with hair bulbs and hair shafts. These include the highly reputable Dr. Junji Fukuda from Japan; and newer lesser known newere entities from South Korea such as Kangstem Biotech and AttisLab.
According to “Theo”, this novel method can produce human hair follicle organoids (including the hair shaft and hair bulb) using only human adult stem cells. In contrast, Dr. Junji Fukuda’s original method used mixed stem cells from humans and mice. Pola Chemical’s technology can also be applied to create human hair follicle primordium, like the Dr. Takashi Tsuji method. It can be used for hair transplantation and hair follicle regeneration.
So if I’m interpreting this correctly, this will provide unlimited hair follicles from ones own stem cells, which can be used for hair transplants?
Yea I’m a little confused too lol
The company has not even started trials yet, but yes, it would represent a hair loss cure if realized.
Nice find Admin.
Thanks to “Theo”, who regularly emails me about Asian companies.
At this stage we need a joint venture with all of these guys coming together to cure us.
Yes of course that’s positive – every company that tries is a plus in my book.
But it looks more like a laboratory-only kind of research without any intent of human trials as far as I can see that. It basically shows what they‘re capable of which is impressive tbh (all cell-types human).
There‘s a couple of companies working on these cell-type therapies, but none is close to human trials. OrganTech might be the exception.
TrichoSeeds and Epibiotech announced trials which never happened – both companies do research and CRO.
Kangstem, Biofab, J.Hewitt, Stemson, HanBio, Theracell, Hairclone, Aderans, Intercytex, Koehler Lab, Stemson, d‘Novo were all complete failures or never proceeded any further – for various reasons.
Lack of funding is main reason. It takes 10 years and a billion dollars to get these solutions through the FDA! Only 24% make it. Pelage works but can it withstand the overwhelming criteria of the FDA.
The overwhelming criteria of the FDA are that it works (and is safe).
Hello, could someone please provide an educated estimate/guess on when the hair cloning/stem cell technology which creates new follicles will become commercially available? Thanks.
Hello Victoria,
The best case scenerio is Dr.Tsuji method right now. The name of the company that pursues this method is OrganTech. Their aim is to bring teeth and hair regeneration by 2026 if everything goes well (personally I think it will be few years later than 2026). This method was supposed to commercialize by 2020, but due to covid, they couldn’t raise money for human trials in 2019-2020 and they went bankrupt in 2021. In 2023 they secured necessary funding and resumed their operations. Me and many other members of this community are rooting for OrganTech to bring this treatment to use as soon as possible. They just applied in December 2024 for human clinical trials to Japanese Health ministry. We all are waiting to see the outcomes of these trials.
Thank you very much Eko. If Tsuji fails, are we doomed? Or when do you think the other hair cloning tech will come out?
My main hope is that some Asian company will “cheat” and skip half the clinical trial length. Dangerous for those of us who are willing to be the initial guinea pigs of course. This is the only reason that I follow Jiankui He on X (though it now seems like some immature person has taken it over).
https://x.com/Jiankui_He
He became famous because of this:
https://www.hairlosscure2020.com/lulu-and-nana-and-scott/
https://www.youtube.com/watch?v=K5ChEUCI4Os
The US cheated when it came to mRNA Covid vaccine speed of development, so maybe the west can surprise us too.
UK trials were supposed to have become faster, but HairClone overpromised.
I don’t want to say doomed but similar other treatments are still in research phase. For them to advance to even human clinical trials would be at least another 5 years. So we would be looking at a more distant future. Hope Tsuji succeeds and we have this in near future. Let’s wait and see.. as always.
Thanks Eko, when do you reckon is the most realistic estimate for commercial roll out? like how many years away?
Tsuji is aiming for trials to take place in Q1 2026, maybe 2-4 years after that. Although, the cost is the bigger issue with OrganTech claiming it would cost upwards of $750k for the primordium treatment for consumers.
China is our only hope, and hopefully it will be as cheap as Temu.