Yet Another Replicel Interview

This one with Lee Buckler, the vice president of business and corporate development for RepliCel.  Few more details on the company’s pending phase II trials, including frequency of injections:

How RepliCel Is Harnessing the Awesome Power of Cell Therapy

Great often missed point:

With a cell transplant, there is no limit to the number of cells we can grow to use in regenerating poorly functioning hair follicles.

I disagree with Lee’s statement that:

Second, hair transplantation only achieves a satisfactory result when performed by a gifted surgeon, of which there are few.

In my opinion, there are at least several hundred great hair transplant surgeons in the world today, and the ARTAS robot is enabling  numerous strip surgeons to become “gifted” when it comes to FUE.  I think in most cases, satisfaction is more closely related to expectations rather than surgeons these days.  A Norwood 5 will not be happy if he expects a Norwood 1 type final result after a hair transplant. Because strip hair transplant surgery is becoming obsolete, scarring and nerve damage are also no longer as big an issue (albeit still possible) with FUE hair transplants.

Another major reason for hair transplant patient dissatisfaction is that the existing hair in the transplanted area will continue to die, even when taking Finasteride for many people.  So in essence, the result immediately post transplant will only continue to slowly worsen in most hair transplant patients.  And in the long run, even the “permanent” transplanted hair is not always permanent, as can be seen in many older people’s totally denuded or sparse donor regions.  In fact even in my 30s, my supposedly “permanent” donor hair at the back of my scalp is significantly less dense than in was in my 20s.

DA-4001 (or DA-4001C)

A few days ago, one of the guests in the hair loss chat on this site posted about a new topical product from South Korean company Dong-A ST called DA-4001 (also referred to as DA-4001C), whose initial 60 person phase 1 clinical trials were scheduled to have been completed in October 2014. These trials commenced in December 2013 and will largely be limited to testing the safety of the product.

In phase 2 clinical trials, the results of DA-4001 are supposed to be compared with the results of 1ml twice a day Minoxidil 5% topical application. (Note: It seems like DA-4001 might be a type of topical finasteride product, but I am not certain and there is little information on this online).

Even if superior to Minoxidil, it will probably be a few years before DA-4001 can come to market, even if they somehow managed to pass similar regulations in South Korea as in Japan in order to skip phase 3 clinical trials.

Nevertheless, this year has been the most encouraging yet in terms of the number of new topical medications in development to counter balding. Although not as exciting as Histogen or Replicel, these products will still be very effective for a lot of people. Hopefully they will even benefit many people for whom Minoxidil and Finasteride did nothing or caused too many side effects.