I have discussed the work of Australian-American Harvard Medical School geneticist, professor and longevity researcher Dr. David Sinclair a few times on this blog. In 2018, I even wrote an entire post devoted to his work on NAD, NMN, Resveratrol and Sirtuins. But too many new updates in that post have made it confusing. So I am now writing a second post on this esteemed scientist who has a knack for being mentioned in the global media on a daily basis.

I have covered the subject of anti-aging in numerous posts due to the fact that any technologies that reverse human aging will also regrow lost hair and re-pigment grey hair. In fact Dr. Sinclair’s Lab is also working on the latter two conditions. The most ambitious of Dr. Sinclair’s projects is a currently secretive drug candidate code-named SL-100 that aims for whole-body rejuvenation.

Life Biosciences: Phase 1 Trial of ER‑100 for Optic Neuropathies

Dr. Sinclair’s company Life Biosciences has been in the news a lot in recent months. They work on cellular rejuvenation therapies to reverse multiple diseases of aging,

Their current focus is on reversing various diseases of the eye that cause vision loss. In particular, optic neuropathies such as open-angle glaucoma (OAG) and non-arteritic anterior ischemic optic neuropathy (NAION).

In January 2026, Life Biosciences received FDA clearance for its Investigational New Drug (IND) application for its ER-100 gene therapy. More on this

“ER-100 originated from Life Bio’s Partial Epigenetic Reprogramming (PER) platform, which aims to restore aged or injured cells to a younger state by modifying the epigenome of cells, biochemical markers that regulate gene expression without altering the underlying DNA sequence.

Life Bio’s approach allows for the controlled expression of three of the four Yamanaka factors, the transcription factors OCT-4, SOX-2, and KLF-4 (OSK), and has demonstrated safety and efficacy in multiple preclinical animal models by local injection into the eye (intravitreally). ER-100 is the first ever cellular rejuvenation therapy using epigenetic reprogramming to receive FDA clearance to enter human clinical trials.”

In April 2026, Life Biosciences received $80 million in Series D Financing. This will allow for the completion of the company’s Phase 1 clinical trial of ER-100 and the continued advancement of its Partial Epigenetic Reprogramming (PER) platform across multiple therapeutic indications. The first patient in the clinical trial for ER-100 was dosed in June 2026.

David Sinclair on The Joe Rogan Experience

Earlier this month, David Sinclair was interviewed on “The Joe Rogan Experience” for a 4th time. In reverse chronological order, below are all of his past appearances on the world’s most popular podcast:

• August 7, 2026: JRE #2537.
• June 18, 2021: JRE #1670.
• September 10, 2019: JRE #1349.
• January 29, 2019: JRE #1234.

He talks about hair regrowth and grey hair reversal starting around 47:30 minutes into his latest interview with Joe Rogan.

He says that he takes sildenafil (Viagra) for his overall vascular health and also for better hair growth.

Lifespan

It seems like “Lifespan” is becoming Dr. David Sinclair’s main brand.

• In September 2019, Dr. Sinclair co-published a book with Matthew LaPlante called “Lifespan” that has become extremely popular in logevity circles. It currently has an average rating of 4.6 out 5 stars based on 12,100 reviews. It seems like this is the second most popular book in the anti-aging segment after Dr. Peter Attia and Bill Gifford’s 2023 book “Outlive” that currently has an average rating of 4.6 out 5 stars based on 21,200 reviews.
• In 2022, Dr. Sinclair launched a new YouTube show called “Lifespan with Dr. David Sinclair“. After not posting any videos on there from 2022-2025, he has been posting new content almost every week for the past three months.
• In August 2026, Dr. Sinclair launched a new website called lifespan.com as well as his new magazine called Lifespan^TM. You can read the August 26 edition in full here.

What Supplements does Dr. David Sinclair take?

In a Tweet from August 3, 2026, Dr. Sinclair said the following:

“I take low-dose daily tadalafil (Cialis) for long-term organ health, especially the brain. Vascular dementia is the second most common and most preventable cause of dementia”

In a 2022 edition of his Lifespan with Dr. David Sinclair podcast that covered “NMN, NAD, NR, Resveratrol, Metformin & Other Longevity Molecules, Dr. Sinclair said that: he recently added Spermidine to his protocol; became vegetarian (while still fasting and eating just once per day); lost 15 pounds; and entirely quit alcohol. Dr. David Sinclair’s supplement list in 2022 included the following:

• NMN (1g per day in the morning with yogurt).
• Resveratrol (0.5 mg per day in the morning with yogurt).
• Metformin (1g per day at night).
• Statin (for cholesterol control).
• Spermidine.
• Vitamin D3.
• Vitamin K2.
• Quercetin.
• Fisetin.

Interestingly, in a December 2023 Tweet, Dr. Sinclair mentioned that Resveratrol and Fisetin (both SIRT1 activators) induce the proliferation of hair follicle bulge stem cells. This in turn promotes hair growth. He certainly looks younger than his current biological age of 57, and he has no balding or grey hair.

Critiques

In my original post about Dr. David Sinclair, I linked to several articles that heavily criticized his past anti-aging claims. And some scientists have accused him of being a salesman with great marketing skills (who overpromises the results of unproven products).

In general, while I find his enthusiasm refreshing, I am not as yet a full fledged fan of Dr. Sinclair. I tend to trust scientists more if they are less active on social media and not too focused on promotional and marketing activities. But we live in a different era. And there must be a good reason that Harvard University (US) has kept the Sinclair Lab running for all these years and given Dr. Sinclair tenure.