Category Archives: Low Level Laser Therapy

Revian Red, LLLT, Low Level Laser Therapy, PhotonMD

Revian Red Light Therapy for Hair Growth

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Note that the Revian Red system is currently on sale on Amazon after coupon discount application. Regular price is $995 on their website. Average reviews for the Revian Red cap so far are 4/5.

Update: January 4, 2022 — Latest clinic trial update for central centrifugal cicatricial alopecia.

Update: January 21, 2020 — Revian Red got very positive and compelling hair growth in final clinical trial results. They used the same primary and secondary endpoints as were used in past finasteride and minoxidil studies. Itching and burning of the scalp was also reduced with device use.

Update: January 8, 2020 — Revian’s new parent company Know Bio product release article. The LED laser light wavelengths are a combination of 620 nanometers and 660 nanometers. Also, Revian received a USPTO patent No. 10,525,275 on the use of proprietary color combinations of light to regenerate living tissue in the body.

Update: September 2019 — September 2019 press release.

Quote from Dr. Rodney Sinclair:

“It took almost 20 years to work out the ideal wavelengths of light, the best fluence or ‘power’, how long the treatments should last and how often the treatments need to be repeated.”

Revian Red Laser
Revian Red Light Therapy for Hair Growth.

It has been a long time since I wrote a post on low level laser therapy (LLLT) to treat hair loss. Although a very controversial subject, there are a number of studies that suggest LLLT can benefit hair growth. There are nowadays many low-level laser devices to treat hair loss.

Almost always, laser therapy will not bring back hair in totally bald areas of the scalp. However, LLLT can make existing hair thicker according to many findings. The latest study in support of low level laser therapy for hair growth was published in Lasers in Medical Science in August 2019.

Revian Red

In April 2019, a new laser system for hair growth called Revian Red entered the market. It is manufactured by PhotonMD (North Carolina). Revian Red is FDA cleared for the treatment of androgenetic alopecia in both men and women. Note the difference between FDA approved and FDA cleared.

Revian Red with Phone App
Revian Red with Smartphone Mobile App.

One of the more interesting aspects about Revian Red is that it is a wireless cap that comes with a phone app that you can use to take photos and track results. The app also reminds you of the 10 minutes per day treatment schedule.

Groundbreaking LED Technology

Also of interest, Revian Red is based on red light emitting diode (LED) technology, which is different from existing LLLT devices. See my past post on laser therapy for hair loss and wavelength. Red light wavelength ranges from 400 nm to 700 nm.

According to company CEO and device inventor Dr. Nathan Stasko, this LED technology is known as modulated light therapy (MLT). According to Dr. Stasko, Revian Red is the first FDA cleared all LED  hair growth product with supporting laboratory data. The latter shows that LED light penetrates the skin better than laser light at an identical fluence of 1J/cm2. Additionally the LEDs are lighter weight and deliver more light with less power, enabling the product to be cordless during its use. He further adds:

“Laser diodes used in LLLT and LEDs are different light sources. Lasers are coherent light, while LEDs are incoherent light with a wide viewing angle. The knock on LEDs was that they were not high power. That is true if you are referring to Christmas tree bulb semiconductor materials. But with the advancement of LEDs (that now even power car headlights), Revian Red devices are able to attain a high output in lumens/watts.”

Clinical Trials

Revian Red underwent clinical trials in Australia that were led my the famous dermatologist Rodney Sinclair. According to Revian’s own site, clinical trial results have been favorable and there are no significant side effects. However, the results are not as yet officially published, even though the trials were completed in May 2019.

Before Revian: Other Laser Devices

I have covered a number of other low level laser therapy devices on this blog in the past. These include combs, helmets and caps. You should check the reviews and ratings of all of the below before making a decision on which device to purchase.

The oldest of these FDA cleared lasers is the HairMax LaserComb, while the more recent of these is the Theradome Laser Helmet. Also cleared are the funky looking iGrow Laser Helmet; the iRestore Hair Growth System; and the Capillus Laser Therapy Cap.

LLLT Wavelength, Blue Light, Fractional Laser, LLLT, Low Level Laser Therapy, Red Light

Lasers, Wavelength and Hair Growth

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I have covered lasers and hair growth on this blog a number of times in the past. A spate of new studies on this subject suggest an emphasis on laser light wavelength during treatment.

New Low Level Laser Therapy Hair Studies

When people discuss laser treatments for hair loss, low-level laser therapy (LLLT) is usually what they mean. There have been many studies done in the past that show LLLT to be beneficial towards scalp hair growth. However, a large number of those studies have been of subpar quality (e.g., small sample size, bad photos) or biased (e.g., sponsored by a laser device manufacturer).

So this subject remains somewhat controversial. However, in the past month, three new studies have been published in support of low level laser therapy to treat hair loss:

  • A 2017 study from China concluded that low level laser therapy stimulates hair growth in mice via upregulating the expression of Wnt10b and β-catenin. Hair follicle count remained the same in LLLT treated mice versus untreated mice, but hair length increased in the former. If this holds true in humans, perhaps LLLT can really make existing hair stronger and less likely to die from the attack by dihydrotestosterone (or at least prolong the battle). However, long-lost hair is probably not going to return from LLLT.
  • A 2017 study from Iran tested a new laser scanner device (with a combination 655 nm red laser plus 808 nm infrared laser) by comparing it with a 655 nm red light laser hat. Both products led to hair growth benefits, but the laser scanner was superior. So laser wavelength may make a difference in outcome.
  • A 2017 study from Egypt on female hair loss sufferers found that combination LLLT+Minoxidil 5% treatment led to the better outcomes (measured via Ludwig scale classification and patient satisfaction) in comparison to LLLT only or Minoxidil 5% only treatments.

LLLT Wavelength: Blue Light > Red Light?

A 2017 study via a European collaboration effort found that a UV-free blue light laser (453 nm wavelength) led to hair growth via prolongation of the anagen phase of the hair cycle, but a red light laser (689 nm length) did not do the same. Update: February 2021 — From the same scientists, a new study on blue light, cryptochrome 1 (CRY1) and hair growth.

This result is surprising since most commercially available LLLT laser products (combs, caps, helmets) are of around 650 nm wavelength (i.e., in the red light spectrum). Interestingly, a 2015 study from South Korea found that 830 nm laser was superior to lower wavelength lasers (of 632 nm, 670 nm and 785 nm) when it came to hair growth in rats.

LLLT Light Wavelength
LLLT Laser Wavelength Spectrum.

The above mentioned European study also made an important finding: “We provide the first evidence that OPN2 and OPN3 are expressed in human hair follicles”.

Update: A November 2021 report finds that photobiomodulation response from 660 nm is more durable than that from 980 nm.

Update: A June 2021 report finds that blue light therapy is a promising therapy for patients affected by androgenetic alopecia. Moreover, blue light-emitting diodes seem to darken grey hair in some people.

Combining Fractional CO2 Laser and Hair Growth Factors

I discussed fractional lasers and hair growth in a post in 2015. Now a new study from China finds that a combination treatment using carbon dioxide fractional laser treatment plus growth factors is significantly superior to using growth factors alone.