Category Archives: Elevai Labs

BosleyMD, Elevai Labs, Mitochondria, Mitochondrial Function, Yuva Biosciences

Yuva Biosciences and BosleyMD New Mitochondrial Upregulation Foam

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I covered Yuva Biosciences (US) very briefly in 2018 in my post on mice and hair growth research. The company founder Dr. Keshav Singh’s team from the University of Alabama reversed skin wrinkles and regrew hair in mice via reversing mitochondrial dysfunction. Also see my other 2018 post about mitochondria and hair and my 2017 post on mitochondrial metabolism and hair growth.

Update: December 9, 2024

Elevai Labs and Yuva Biosciences Launch Root Renewal System

Elevai Labs (US) just announced the launch of its S-Series Root Renewal System™ for the hair care market (h/t “Nick”) via its wholly owned subsidiary, Elevai Skincare. The Root Renewal System is a 3-part hair and scalp care system consisting of a shampoo, conditioner and serum. It combines the latest in patent pending exosome and mitochondrial technology to target scalp health and hair growth at the cellular level. The initial launch will focus on medical aestheticians. A broader consumer rollout is planned for the US in January 2025.

Elevai Labs is one of the world’s leading suppliers of topical exosomes for the hair growth market. The Root Renewal System incorporates two proprietary technologies from Elevai Labs and Yuva Biosciences (US).

  1. Elevai PREx Exosomes™.
  2. The Y100™ small molecule from Yuva Biosciences that improves mitochondrial function. I discussed YuvaBio® Y100™ in the original version of this post below due to the February 2024 launch of the Revive+ Densifying Foam via a BosleyMD and Yuva Biosciences partnership.

February 27, 2024

Yuva Biosciences and BosleyMD Release New Hair Loss Foam Product

On February 20 2024, that Yuva Biosciences successfully raised $7.5 million in seed funding (led by VentureSouth). More importantly, it recently released its mitochondrial upregulation related hair loss product in partnership with BosleyMD. The separate (but related) Bosley is the most renowned name in the world of hair transplant chains. A newer summary of this development was posted by reader “Fynn” yesterday.

Bosley CEO Dr. Ken Washenik declared that:

“We believe this is one of the biggest innovations in hair loss we’ve seen in twenty-five years.”

Revive+ Densifying Foam

Yuva Biosciences BosleyMD Revive+ Hair Loss
Yuva Biosciences BosleyMD Revive+ Foam for Hair Loss.

The new topical product is called “Revive Plus Densifying Foam” and it incorporates Yuva Bio’s Y100 trademarked technology (YuvaBio® Y100™). It contains the Amla plant and up-regulates key genes that restore mitochondrial function. In the process hair loss is reduced and hair regrowth is possible.

It is now available for sale on Amazon (image on right) at a price of $44 for a 2-month supply. The current 20 reviews with an average rating of 3.9 out of 5 stars praise the product’s ease of application, non-irritation and non-greasiness. Also see the announcement on Linkedin.

Yuva Biosciences developed this topical foam based hair loss product as follows:

“Using AI, the company combed through thousands of molecules to identify those with the greatest potential to boost mitochondria levels in skin and hair cells, leading to the discovery of its lead compound, Y100.”

Among the ingredients in this product include terminalia chebula extract, biotin, asparagus racemosus root powder, and leuconostoc/radish root ferment.

Also of significance, the Y100 mitochondrial function restoration lead compound molecule is just the first to market. Yuva will continue to use AI to develop other molecules that target mitochondrial dysfunction in order to combat hair loss.

Interestingly, Yuva is also partnering with Elevai Labs, one of the leading suppliers of exosomes to the hair growth market. Note that BosleyMD also sells a popular Follicle Energizer product that contains hair friendly natural ingredients such as caffeine, biotin and soy.

Dr. Keshav Singh

Dr. Keshav Singh is the Chief Scientific Officer and Co-Founder of Yuva Biosciences. He is a Harvard-trained researcher, the founding Editor-in-Chief of the journal Mitochondrion, and the author of over 100 scientific studies on mitochondria. Dr. Singh is active on Twitter (X) via @mitoscientist. Also check out @YuvaBio.

For a long time it has been known that mitochondrial dysfunction is a key factor in aging. However, Dr. Singh was the first to discover and prove experimentally that mitochondrial dysfunction is a key cause of hair and skin aging. I discussed his groundbreaking 2018 study in my earlier mentioned post on mice hair growth research.

Company co-founder and CEO Greg Schmergel is an accomplished entrepreneur. Also working with them is Dr. Shekhar Mitra, a past Senior Vice President of Corporate Innovation at Procter & Gamble.

The Y100 mitochondrial technology was identified using Yuva’s advanced artificial intelligence platform called “MitoGPT”. This was co-developed by Dr. Keshav Singh and Dr. Jeb Linton (an IBM data scientist).

Calecim, Elevai Labs, Exosomes

Topical Exosomes for Hair Growth

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In 2019 when I first discussed exosomes for hair growth, most doctors were injecting them into the scalp. Recently, I also discussed the rarer intravenous (IV) delivery of exosomes to tackle hair loss. Now I look at the topical application of exosome serums into the scalp, due to three such new products being in recent news.

Note that some injectable products from exosome suppliers to the hair loss market can also be applied topically. The method of delivery will depend on your doctor’s or clinic’s preference.

Calecim (PTT-6) Advanced Hair System with Topical Exosomes

Calecim PTT- 6 Topical Exosomes
Calecim (PTT- 6) Advanced Hair System: Topical Exosomes and Growth Factors for Hair Growth.

Recently, HairClone (UK) announced a partnership in which the company will work with an interesting new exosome containing topical product called Calecim Advanced Hair System (that comes with a Derma Stamp).

Edit: The manufacturer has now given blog readers a 15% off discount code “HLC2020“ for purchases of the Advanced Hair System kit. And from November 8 to December 2, every purchase of the Advanced Hair System kit will get a FREE Advanced Hair System 2x5ml OR Restorative Hydration Cream 1x50g. Save up to $195!

This Calecim product includes PTT-6®, which contains over 3,000 proteins, including growth factors, cytokines and exosomes that signal cells to regenerate.

PTT-6 is derived from the secretion of cord lining stem cells isolated from the umbilical cord tissues of New Zealand red deer at birth. No deer is harmed during the extraction and harvest process of this rich source of stem cells.

Calecim Dermastamp
Calecim Dermastamp Included.

The full list of ingredients is PTT-6® and cord lining conditioned media (from stem cell derived fibronectins, glycoproteins, albumin, collagens and hyaluronic acid).

This Calecim topical serum is to be used with an included Derma Stamp for better absorption. A lot people underetrake at-home microneedling for similar reasons. This includes via dermarollers or dermapens or dermastamps.

Elevai Exosomes Combined with Yuva Biosciences Mitochondrial Technology

Elevai Topical Exosomes
Elevai Topical Exosomes for Hair Growth.

Elevai Labs (US) recently gave a positive update regarding the company’s topical Elevai “age zero” Exosomes™ product range for hair loss. In a year-long study that the company conducted, patients who used Elevai empower™ exosomes in combination with in-office microneedling saw favorable results. The company also makes Elevai enfinity™ for at-home use in repairing your skin.

The 12-month results were assessed using imaging analysis and showed a cessation in crown inflammation, a reversal of miniaturized hairs, and a recovery of hairs from the dormant resting phase. the still on-going research study is being conducted in partnership with Carly Klein, president of the National Hair Loss Medical Aesthetics (NHLMA).

Note that I previously also discussed Elevai in my post on Yuva Biosciences and BosleyMDs new hair loss product related to mitochondrial upregulation. Yuva is partnering with Elevai to release a hair loss product that will combine Elevai’s proprietary PREx™ exosome technology with Yuva’s Y100™ mitochondrial technology. The two companies jointly filed for a combination patent in August 2024.

Ultimately, Elevai is developing a new hair and scalp care product line, called “Elevai S-Series Root Renewal System” that will be powered by exosomes and mitochondrial technology. According to company CEO Dr. Jordan R. Plews, they are in the process of conducting a follow-on study. This will further analyze the combination of Elevai exosomes and Yuva’s Y100 mitochondrial technology to address hair loss and thinning concerns.

ExoCelBio Evovex Serum

Another company that makes a line of topical exosomes is ExoCelBio (US) via its Evovex serum. The company website says that these exosomes are derived from the chorion of placental mesenchymal stem cells (pMSCs). Their Exovex™ serum Refine brand was launched in 2023 and has a concentration level of 75 billion exosomes per vial. Refine employs a high concentration of non-lyophilized, purified exosomes that results in fuller and stronger hair.

In May 2024, the US FDA sent a violation warning letter to ExoCelBio in relation to the company’s marketing and lack of a biologics license. This is not surprising, considering the new stricter FDA guidelines governing exosome products. In the US, exosomes are regulated as both a drug and a biologic. In Europe, you are not even allowed to use human-derived exosomes to treat hair loss.