Category Archives: Colin Jahoda

Person to Person Hair Transplants Revisited

Modern hair transplants generally produce quality results. However, the biggest disadvantage of hair transplants remains the fact that people have limited donor hair at the back of their scalps in the safe “permanent” zone.  Men with large bald areas will usually not get great results from a hair transplant unless their coverage expectations are modest and they do not mind seeing barren scalp on days when their hair becomes wet in the rain or disheveled by the wind.

Because of this lack of sufficient donor hair supply, one would wonder why person to person hair transplants have not become more common?  The obvious and most cited explanation from hair transplant surgeons is that due to the requirement of taking anti-rejection medications (immunosuppressants) for life, person to person hair transplants are almost never approved. Taking immunosuppressants for life carries significant health risks, although from what I have read in numerous organ transplant stories, no-one seems to be dying from this and people monitor themselves daily when taking such drugs.  I wonder how many people below the age of 60 die from the side effects of taking immunosuppressants?  Moreover, it seems like physicians are getting closer and closer to weaning organ recipients off of immunosuppressants entirely!  That would be a miracle.

In any case, even if proven to be very safe with a great chance of getting weaned off them in the long run, I would still not want to take such drugs just to get more scalp hair.  Therefore I was not planning on writing a post about person to person hair transplants due to their being unlikely to ever become popular…..until yesterday, when I reread the summary of a groundbreaking experiment from 1999 by Dr. Colin Jahoda on his wife Dr. Amanda Reynolds.

Dr. Jahoda transplanted several of his scalp hairs to Dr. Reynolds arm, and four hairs then grew on Dr. Reynolds arm.  I had heard and read about this well known experiment numerous times in the past, but forgot to ever check if Dr. Reynolds took immunosuppressants. Then I read the below in the above linked article and felt like a lightening bolt struck me:

Apart from its theoretical use in cosmetic medicine, the experiment reveals that hair follicles are one of the rare tissues apparently capable of being transplanted from one body to another without rejection. Why evolution has endowed them with such “immune privilege” is a mystery.

This makes me wonder why more surgeons have not attempted person to person scalp hair to scalp hair transplants?  In one of my past posts where I briefly mentioned person to person hair transplants, one commentator suggested that you could never get another living person to donate his/her hair to you.  I think that is absolutely incorrect.  If I had a very full thick head of hair and someone offered me say $100,000 to donate 20 percent of my scalp hair, I would be more than happy to do it (especially if the hair is taken from the back).  If it were a good friend or family member, I would probably do it for free.

Going back to the above article, it seems like Dr. Jahoda transferred dermal sheath cells rather than actual hair, even though full hairs were extracted from Dr. Jahoda’s scalp prior to extraction of the dermal sheath cells from them via the use of a powerful microscope. Dr. Jahoda holds a patent on this procedure, and I might contact him to see what came of it.  He did have some doubts about the hair cycling normally or not after one round of shedding was over.

Although I was excited by this new finding on my part after re-reading the summary of the Jahoda experiment, considering that it all happened in 1999, I think there must be some sound explanation behind person to person transplants never taking off.

I nevertheless did some more googling on this, and came across an interesting comment from 2009 that is pasted below.  Usually I do not like to quote comments from internet based forum members, but this one from Marion Landan on the regrowhair site seems somewhat legitimate and sincere to me:

Just want to correct what you are saying about hair transplanting from another person. The people do not have to be identical twins or even related to one another. I have been told by a retiring hair transplant expert who tried some of these surgeries that sometimes it works and sometimes it doesn’t. Just as there was a learning curve for transfusing blood, there are things not understood about why hair can be transplanted sometimes from an unrelated donor, and sometimes can’t even be transplanted between identical twins (possibly with the twins the bald brother had an infection that caused his original hair loss, after transplantation from his brother, his head swelled up and rejected the new hair). I have also been told that hair transplanting between people was made illegal in the United States several years ago — so doctors no longer try it.

Why would this have been made illegal?  Were there serious side effects involved?

Also interesting: if you get someone else’s bone marrow, you can also get their scalp hair.

Also interesting: from 2007, the famous facial transplant surgeon Maria Siemionow thinks it will soon be possible to transplant an entire scalp from a dead person to a live one, and it might just require a limited time on immunosupressants.  Half of Dr. Siemionow’s prediction came true in 2015 (see next sentence below).

And also interesting right from this blog: first ever skull and scalp transplant.

Finally, it seems like there are certain commonalities between donor and recipient that might increase the likelihood of survival of organs and tissues after a transplant.  These can include blood type, certain common genes and more.   Transplant survival rates with or without anti-rejection medication will continue to improve as researchers uncover more details regarding such issues.

Theracell — Cell Based Hair Follicle Regeneration via 3D Culturing

A new player has entered the hair loss world by the name of Theracell.  Interestingly, the company is headquartered in the UK, but its laboratory is in Greece and its management team is entirely composed of people with Greek names.

More importantly, the management team is composed of very experienced PhDs.  Even more importantly, the team members with photos are all somewhat balding.  I tend to assume that balding people are usually more passionate about curing hair loss than are non-balding people, although that is of course not necessarily true.

Theracell is trying to regrow hair via cell-based hair regeneration. They state that they will isolate stem cells from 10-20 follicles and use 3-D culturing to increase their numbers significantly prior to injecting them into the scalp as pre-follicular units.  I wonder if their 3-D culturing method is similar to that developed by the renowned Colin Jahoda?

Although their cell-based hair regeneration page linked above did not specifically mention dermal papilla cells, the company is culturing dermal papilla cells per other parts of their website. They also list the name of their hair regeneration product as TC-RBD-5131, with “RBD” standing for Regenerative BioDermatology. The company is involved in a few other areas of medicine besides dermatology.

Perhaps I am being a bit too discerning, but on Theracell’s home page, I was quite surprised to see the word “Careers” in the top upper right spelled as “Carreers”.  Quite a few photos on the site are not loading, while there are various other typos and inconsistencies. I would not be surprised if the company currently has few employees and limited funding as is often the case with some of the newer companies that I have covered on this blog.

But I will repeat…..thankfully, the management team is balding!  It also seems like for a small country with just 11 million people, Greece is disproportionately represented in the hair transplant world.  There are quite a few hair transplant surgeons based in Greece, and the well known hair transplant behemoth DHI Global is headquartered in that country.

As an aside and totally off-topic (except a connection with Greece) conclusion to this post, I have always felt that people who have a lot of body hair, especially back hair, tend to go bald much faster than people without much body hair and have said so before on this blog. I reached that conclusion over a decade ago based on what I observed in my own extended family and from what I have since observed in gym and swimming pool changing rooms.  Of course there are always exceptions to this rule, but the correlation is very strong. Many Greeks/Persians/Armenians are known to be very hirsute when it comes to their body hair, yet balding on their scalps. I started to notice this phenomenon over a decade ago when I was an avid tennis fan and followed Andre Agassi (Persian ethnicity) and Pete Sampras (Greek ethnicity).  I am convinced that Pete Sampras has had a hair transplant since he retired.