Hair Loss Chat is Restarting

In 2014, I created a hair loss chat for this site (see bottom of this post). However, the free plugin that I used was not that great. Moreover, after a while, I lost patience in dealing with excessive spam and trying to commit myself to be present regularly.

Hair Loss Chat and Talk
New Hair Loss Chat Screenshot.

New Hair Loss Chat

September 20, 2020

Recently, one of this blog’s readers encouraged me to create a hair loss chat on Discord. After a day of hesitation, I started the chat last week. So far, it has been going great (expand screenshot above) with no spam. I initially only invited people who emailed me useful intelligent information at least a few times over the years.

I now want to invite other serious people so that we can get at least 50-100 regular participants. If you are interested in joining, please post a comment in this post under your existing username and, if possible, legitimate email address. Thereafter, email me using the same email address and let me know your blog username and why you want to join the chat. Also your city/state/country location. If you do not post comments on here but have a solid posting history on any of the hair loss forums out there, let me know too for verification purposes. If all seems ok and I feel like you will not spam the chat, I will send you an invite link. My e-mail can be found in the contact us page. Make sure to check your spam folder for my reply in case it goes there.

Initial preference will be given to those who have made mostly useful comments on this blog in the past. These do not have to be scientific comments. As long as you have been courteous, I am okay with your participating in the new chat.

For the most part, this chat will help people looking to compare their existing hair loss treatment regimens with others and make improvements. Including by using newer products, delivery mechanisms and alternative or esoteric ingredients. I hope to benefit from this information too.

I would not recommend joining the chat just to always vent. Nor just to always complain about delays in future hair cloning and hair multiplication related prospects and trials. Some venting and complaining will be acceptable.

The moderation in the hair loss chat will be very strict. If anyone posts dozens of emotional comments in a day with nothing useful to say, they may get banned. It is unfair to have intelligent comments move out of the screen view due to one person posting lots of garbage daily and monopolizing the chat window.

If anyone looks like they are there as a hair transplant surgeon representative or are primarily there to promote specific products, they will be banned. If anyone keeps repeating that there will never be a hair loss cure, they will likely get banned. Any excessive cursing or insulting of other chat participants (or even doctors and surgeons) will be grounds for being booted. Any excessive political or religious discussions will also be frowned upon.

I am sure that 100 percent scientific and technical discussions can get dull and dissuade those who are not interested in chemistry and biology. So I will give some leeway for off-topic comments. At least in the general chat channel.

In all likelihood, if we reach over 50 participants, I will hand over moderating duties to a regular chat participant. I will rarely have more than a few hours a week of time to devote to the chat.

Channels

In chats on Discord, you can break things into channels to separate key subjects of interest. Among the hair loss related subjects that most interest me at present include:

Please do not be disappointed if you are not invited immediately. I want to be selective initially and see how it goes. I do not want to waste my time again by accepting spammers, trolls and overly negative people.

October 31, 2014 — Hair Loss Chat

I recently installed chat functionality on this site. See hair loss chat for more details. I initially allowed anyone to post, but due to spam, you now have to register. If popular, I might pay to get a better chat on the site in the future. The current one is based on a free plug-in.

Also, if people are keen, I can arrange a once a week fixed chat time when many people show up at the same time. I cannot promise to be there each week. Please post recommendations on the time and day when you prefer to chat under the comments to this post. Try to post Eastern US time preferences to keep things easy for me. I am located in the Pacific zone.

FOXO4, Anti-Aging and Hair Growth

I previously wrote about FOXO4 in a post in March 2017 that covered Dr. Peter de Keizer and his groundbreaking findings. In brief, interference via a newly created modified FOXO4-p53 peptide caused senescent cell apoptosis (death) in mice. Subsequently, the mice became younger and healthier. Most importantly, the mice regrew thick and robust coats of fur.

In the above study, the FOXO4 peptide was created in a D-retro inverso (DRI)-isoform conformation and named FOXO4-DRI. The anti-aging and hair growth related findings of this work were widely covered by the media in 2017. Dr. Keizer thereafter started his own biotech company called Cleara Biotech.

Senescent Cells

I have written about senescent cells (undesirable) and senolytics a number of times in the past. In an interview with Dr. de Keizer, he mentioned the following:

“If you remove the senescent cells, it means the (neighboring) stem cells can differentiate again, supporting tissue rejuvenation.”

Also make sure to read my related post on NAD, NMN and Resveratrol for aging reversal.

Hyperbaric Oxygen Treatment

Earlier this week, an anti-aging breakthrough from Israel was widely covered in the media. Apparently, giving pure oxygen to older people while in a hyperbaric chamber increased the length of their telomeres by 20 percent. More details here.

This development is impressive because it resulted in both:

  1. Telomere Elongation. And:
  2. Senescent Cell Reduction.

There have already been other methods via which people have increased their telomere length, including TA-65, exercise, diet and caloric restriction. However, this new hyperbaric oxygen treatment (HBOT) protocol led to elongation of telomeres at higher rates in comparison to existing interventions.

Using FOXO4 for Hair Growth

I was not planning to write about the above findings from last week as there did not seem to be any connection to hair loss.

However, earlier today, reader “egghead” posted a new link to the same story. More importantly, he made an astute observation in regards to the video at the bottom of the just mentioned Aljazeera link. He watched it entirely, and found an example of hair growth from FOXO4-DRI in the second half of the video.

Unfortunately, I cannot embed the video here, but below is the most relevant screenshot:

FOXO4-DRI Hair Growth.
Using FOXO4-DRI for hair growth.

FOXO4-DRI

Apparently, many people have been taking commercially available versions of the FOXO4-DRI peptide. Both for longevity reasons and, in rare cases, for hair growth. The above screenshot is from someone named Darren Moore and you can read his story on his site. Also see this article on his before and after hair growth.

Although Darren initially regrew his hair and it became darker, it seems like he lost most of the gains per this interesting 2019 video about him. During a brief perusal of Darren’s blog, I noticed that several commentators posted that they saw darker and fuller hair when taking FOXO4-DRI. There is also a 29-page group buy thread on this subject on the longecity forum.

I am surprised that people trust this untested and expensive chemical. It is even on sale on Amazon. Who knows if there are any long term side effects. In an interview on Linkedin, Dr. Keizer stated the following:

“We have now also received emails from people from America, for example, who have already bought the drug, the anti-aging substance FOXO4-DRI. You can now get it on the market in China. For a thousand euros you can buy ten milligrams and that is enough for a third of one treatment.”

I am not sure how the product that Dr. Keizer and his team developed (and patented) can be replicated by these Chinese labs. Even US companies such as Bucky Labs sell FOXO4-DRI for “scientific research use”. I assume all commercial versions of the drug have minor differences.

My Thoughts

I would not take this product in the hopes of re-growing my hair. Too little anecdotal evidence for that as of right now. Not to mention that the price for a full dose treatment is quite prohibitive. However, this whole FOXO4 subject matter is worth following in the coming years.

In an e-mail, Dr. Keizer told me that they were certainly not going to ignore hair growth results during their future research. However, cancer treatment and anti-aging remain their top priorities.

Perhaps localized senescent cell destruction in the scalp region will be possible via topical products in the future? Maybe this could then regrow hair via enabling nearby hair cells to function properly again?