Questions for Dr. Alexey Terskikh

I have covered Dr. Alexey Terskikh (who works at the Sanford-Burnham Medical Research Institute in California) a few times in the past on this blog before. My main post on him and his pluripotent stem cell related work from almost exactly two years ago can be read here.

Recently, commentator “Sets” has contacted me a few times in order to see if I, with his help, can set up an interview with Dr. Terskikh. “Sets” is in regular touch with Dr. Terskikh on Facebook and has been acting as the in-between contact person between myself and the doctor/researcher.

I tried to contact Dr. Terskikh several times in the past, but he never responded until recently (and that to an e-mail I sent him 7 months ago after “Sets” asked him to look for it!). It seems like the doctor is easier to contact via Facebook, which I have not used in 1.5 years, so “Sets” is doing the grunt work for us. Please do not e-mail Dr. Terskikh as I am sure he gets 100s of them every day and is highly unlikely to respond in any great detail if at all.

In any event, if you have any questions that you want to ask Dr. Terskikh, please post them in the comments to this post and I will pick the most scientific/technical ones as well as the most interesting non-technical ones to ask him. Of course his willingness to respond will be dependent upon “Sets” much more so than upon myself:-(

On Twitter Dr. Terskikh has mentioned the need to raise $3 million to $5 million in funding in order to proceed with his team’s groundbreaking stem cell based hair growth related research. In his recent e-mail to me, he said they need $1 million to “quickly complete all preclinical studies and move into clinic“. As most us know, hair related research and clinical trial funding are never even a remote priority for governments, universities or scientific institutions. If any of the readers of this blog is super wealthy, maybe give away $1 million to Dr. Terskikh to speed things up for all of us.

Kenogen: A New Phase of the Hair Cycle?

Earlier this month, an interesting new study was published in the Experimental Dermatology journal by UK based scientists. The title of this study was “Hair regrowth in male and female pattern hair loss does not involve the conversion of vellus hair to terminal hair“.

Basically, the scientists found that when medications such as minoxidil, finasteride and anti-androgens were used to treat hair loss patients (both men and women), the resulting hair regrowth was almost entirely attributable to the reactivation of dormant non-vellus hair follicles (termed as “kenogen” hair follicles) rather than the conversion of fine miniaturized vellus hair into thick terminal hair.

This is a very surprising finding since in both male pattern hair loss (MPHL) and female pattern hair loss (FPHL), terminal hair miniaturizes via shorter and shorter growth cycles and finally becomes vellus almost invisible fine hair. I am pretty certain that it has long been assumed that hair loss medications cause some of these vellus hair to become terminal hair once again (if I have time later this week, I will try to find studies in support of such a theory). However, this latest study suggests something entirely different by concluding that:

We would propose there is a population of growth restricted (dormant/kenogen) non-vellus hair follicles, which are re-activated by effective medical treatments as an explanation for the increased hair growth observed in FPHL and MPHL. Our findings have a fundamental impact on the pathophysiology of hair changes occurring in patterned hair loss.

Hair Follicle Growth Cycle and Phases

We have all heard of the three main phases of the hair follicle growth cycle in anagen (growth), catagen (transition/regression) and telogen (resting). There is also a lesser known phase called exogen, which is when hair follicles undergo shedding. Also see my post on telogen effluvium.

However, I had never heard of this new kenogen phase before. A basic google search showed that while this phase is almost never mentioned in literature, it was discovered as early as in 2002 when a study titled “Kenogen. A new phase of the hair cycle?” was published in Italy.

I am not sure if just several studies on this are sufficient to make any conclusions, but it is hard to believe that there could be some follicles in a dormant state that were previously unaccounted for and that are being reactivated by hair loss medications.