Update on Breezula (aka CB-03-01)

In 2014, I wrote about a new yet to be released topical antiandrogen product called CB-03-01. Historically, antiandrogen products have usually been ingested orally and often led to adverse side effects. Early reports suggest that topical CB-03-01 has no significant side effects.

In 2015, the Italian company (Cosmo Pharmaceuticals) that was compounding CB-03-01 changed the product’s name to the unusual Breezula. Moreover, Cosmo itself was renamed as Cassiopea. I wrote about those developments here.

Breezula Phase 2 Results

Yesterday, Cassiopea released an interesting PowerPoint presentation summarizing 2015 and projecting the outlook for 2016. Edit: Link no longer working.

For us hair loss sufferers, pages 18-22 summarizing Breezula’s Phase 2 Proof of Concept (PoC) results is the most important section.

To summarize in brief:

  • 95 patients were enrolled in a double blind study that lasted for 6 months and ended in December 2015.
  • 31 patients were on Breezula 5%, 31 patients were on Minoxidil 5% and 33 patients were given nothing except a vehicle (i.e., placebo).
  • Of the 95 patients, 78 lasted till the end of the 6-month treatment period, and 73 of those were deemed to have completed the protocol without any violations. Of those 73 patients, 23 were on Breezula, 25 were on Minoxidil and 25 were on a placebo. A fairly even distribution.
  • 39 percent of patients on Breezula had at least some improvement in hair growth, compared to 36 percent of those on Minoxidil. 26 percent of patients on Breezula had at least some worsening in hair growth, compared to 16 percent of those on Minoxidil. Status quo was maintained in 35 percent of Breezula patients versus 48 percent of Minoxidil patients.
  • Later in 2016, Cassiopea will commence further dosing related trials for Breezula. I wonder if they will compare the effectiveness of higher doses to the effectiveness of the much more rarely used Minoxidil 15%?

I was pleased to see the results. Overall, Breezula seems as good as Minoxidil, and since the latter is not an anti-androgen, we can use both products topically on our scalp for two separate positive effects. Perhaps we can also add topical Bimatoprost and topical Finasteride to that combo later this year, and then we would have a quartet of topical products, each tackling a different mechanism of balding.

Future Release Date

Of course Breezula is still years from release (even if we assume they can speed up phase 3 trials like is the case in Japan, with newer regulations), but some people on hair loss forums are purchasing it illegally or even making it at home. An even more optimistic scenario is the addition of Samumed’s topical SM04554 to the mix whenever that comes out. It would be funny if in 2020, I started applying a quintet of topical products to my scalp and then suddenly a simple cure for hair loss came out that made all those topical products obsolete.

For younger people who have only been balding for a few years or less, such incremental developments are probably not too exciting. For those of us who have been following the hair loss industry for many more years, it is very pleasing to finally see new products arriving. It is ridiculous that there have only ever been two products officially FDA approved to tackle hair loss — 1) Finasteride and 2) Minoxidil.

***Note that on page 8 of the PowerPoint presentation they have labeled CB-03-01 as “Winlevi” and CB-03-11 as “Breezula”. Winlevi (for acne) and Breezula (for hair loss) contain the same key antiandrogen ingredient (a steroid belonging to the family of cortexolone derivatives), but in different formulations.

John Travolta gets a new Face and a new Toupee

I was not planning to write a new post today, but several interesting developments have made me change my mind.  There will probably be two posts in the next 24 hours. I have some free time on my hands, and a Rockstar energy drink in stock. To the 3 people who I recently discouraged from making too many unrelated comments every day, you are all welcome to post at least 10 comments to this post if you are still reading this blog. This is your time to shine. I want my rare celebrity hair loss posts to also be popular or else this blog will get boring and repetitive. Such posts are also perfect for you to vent with shallow points, bickering and three word sentences.  I dislike it when that happens in my more relevant and hopefully intelligent posts.

I really like John Travolta. I have enjoyed some of his movies a lot; he is a great dancer; he seems to be a great family man; and I always have compassion for celebrities who wear weaves or toupees or hairpieces. Celebrities with fake hair such as Mr. Travolta also indirectly help hair loss sufferers. In 2013, I discussed Mr. Travolta’s luxurious weave. In 2015, in my brief items of interest post, I discussed his at the time shocking first time ever appearance without any attachment on top.

Now comes the biggest surprise yet. Mr. Travolta, who turned 62 last week, has a new face. The new visage is a bit too similar to Arnold Schwarzenegger’s face, and a somewhat creepy development since Mr. Travolta was in the 1997 face swapping movie called Face/Off. Mr. Travolta also has a less luxurious hairpiece these days, and it looks excellent in my opinion. Perhaps John Travolta is just aging and only had minor modifications done to his face. However, people who watched his new TV show “The People vs OJ Simpson” are very taken aback and discussing this development all over social media. His eyebrows definitely gained more hair!

Photos below are in most recent to least recent order for the three developments that I just discussed.

Image of his new face in here (2016).

John Travolta balding photo (2015).

And with a hairpiece (2015).