Dr. Hasson Updates us on Topical Finasteride

In June 2014, I wrote a popular post on topical finasteride that I  have since updated a few times. Shortly thereafter, someone from the Hasson & Wong clinic in Vancouver, Canada e-mailed me. They wanted to let me know that they now prescribe topical finasteride for hair loss.

Fast forward to several days ago, and Dr. Victor Hasson posted a detailed comment in that original blog post. I thought that his comment deserved its own post. Here is Dr. Hasson’s update:

Our topical finasteride solution that we have been using for the past 2 years has proven to be very effective. It has been used primarily in patients who had been experiencing side effects on the oral drug. These patients have been free of side effects on the topical formulation.

This is a good sign that the drug is unlikely to be going systemic via cutaneous permeation. We are currently performing tests using Franz diffusion cells with the The University of Milan to get more data.

Once we have secured a reliable source for dutasteride we will start testing topical formulations with this drug as it will likely be more effective.

A new liposomal formulation of topical finasteride is currently available to our European patients. It has been developed in collaboration with Farmacia Parati in Italy. This preparation can be obtained from this company. You will require a physicians prescription for this, as the formulation needs to be compounded on a case by case basis. This is in order to comply with European and FDA regulations.

Victor Hasson MD

I am impressed by the efforts that the Hassson & Wong clinic is putting into creating their own topical finasteride and topical dutasteride products. A 2007 study on liposomal delivery of finasteride suggests that this route  will be effective.

If the results from these topical products consistently prove to be as good or superior to oral finasteride, this development will be a game changer. Especially if there are fewer side effects.

Sox9 and the Hair Follicle and Biohacking

Sox9 and the Hair Follicle

— An interesting paper (with Elaine Fuchs as a co-author) on how hair follicle stem cells have a strong sense of identity even after being taken out of their home in the hair follicle and then cultured. The Sox9 protein is the “pioneering factor” in all this.

— The coming age of senolytics. I like to say “coming age of…” a lot these days, and it seems like I am far from the only one. A great article was published last month on Novartis’s push for the first ever anti-aging pill. Make sure to also read my past posts on anti-aging.

— New treatment targeting interleukin-23 could be a break-through in the treatment of psoriasis. Note that interleukin-6 has been associated with hair loss and I might write a post on that in the near future.

— Apparently, all brown eyes can be changed to blue eyes. I have brown ones and will only change them if they can figure how to make them green or golden.

— The world’s first penis transplant, if you discount an earlier one done in China a few years ago that was not entirely successful. Finding a donor is not so easy though.

Biohacking and CRISPR

— An interesting new video on out of control biohacking and its dangers. If you have a DIYbio branch near you, probably worth a visit.

— Also see biohacking and DNA modification in someone’s home. The era of synthetic biology scares and excites people at the same time. Some person will sooner or later purposely create highly destructive organisms.

Scientists warn against editing embryos. More on “DNA Scissors” and CRISPR here. A great new article on engineering the perfect baby. I think a perfect baby is one that never poops or cries, but I doubt that dream will ever be realized.