Wharton’s Jelly Derived Mesenchymal Stem Cells and Hair Follicle Generation

Update:  I e-mailed Dr. Omar Aljitawi to ask him two questions (thanks to commentator “Jayjayaustria” for suggesting the first one) about this posts’s subject matter.  Then I sent him a second e-mail for further clarification.  Below are Dr. Aljitawi’s responses:

E-mail 1:

Admin: Since most people in the world have not saved their umbilical cord at birth, how would they benefit from this technology? Would you extract their stem cells from the Wharton’s jelly found in the eyeball region?

Dr. Aljitawi: I have not looked into other mesenchymal stem cell sources. For those who do not have their own umbilical cord MSCs saved, it might be possible to use third party MSCs.

Admin: Is there any reason that this technology has not proceeded any further insofar as getting to clinical trials? Are you actively looking for funding?

Dr. Aljitawi: Funding is certainly one obstacle. Finding expertise in the area to collaborate with is another obstacle. I am working on these obstacles now and I am very optimistic that we can move things forward faster, hopefully soon.

E-mail 2:

Admin: If you do use third party MSCs, is there a chance of rejection? Is it similar to using someone else’s organ during an organ transplant and than taking organ rejection medications for life?

Dr. Aljitawi: It remains a concern. However, the hair follicle is immune privileged, so that might not be an issue.

Umbilical Cord Wharton’s Jelly Superior to Umbilical Cord Blood

In my last post I mentioned the potential importance of storing cord blood (which is a sample of blood taken from a newborn baby’s umbilical cord).  In a surprising coincidence, today I read a highly interesting new study summary pertaining to umbilical cord derived Wharton’s jelly mesenchymal stem cells (WJMSCs) and hair follicle regeneration.

Wharton’s jelly is a gelatinous substance within the umbilical cord (as well as in the eyeball region).  Typically, mesenchymal stem cells (MSCs) are derived from 1) Wharton’s jelly of the umbilical cord or from 2) umbilical cord blood.  However, there is a much higher concentration of MSCs in Wharton’s jelly in comparison to cord blood

Ectodermal Differentiation of WJMSCs and Hair Follicle Generation

In this latest study, the authors show the mechanisms underlying ectodermal differentiation of WJMSCs.  It should be noted that in 2013, two of the co-authors (Aljitawi OS and Hopkins RA) of this latest 2016 study first showed that they could generate cytokeratin 19-positive cells and hair-like structures from WJMSCs in vitro.  They summarized their results from 2013 as follows:

In one method, WJMSCs were seeded on a matrix isolated from Wharton’s jelly following decellularization. In the other method, WJMSCs were cultured to form spheroids. Our findings demonstrate that WJMSCs may have the capacity for ectodermal differentiation.

I have discussed 3D culturing and 3D spheroids many times on this blog in the past, and that subject is of foremost importance when it comes to hair cloning.  For the scientists among this blog’s readership, the patent for this technology has some detailed information on the spheroid technology being used (especially in sections 0065 through 0067).

Two of the latest 2016 study’s authors (Jadalannagari S and Aljitawi OS) also authored yet another paper in 2015 outlining the potential application of WJMSCs for tissue engineering and regenerative medicine applications.

Finally, in this latest 2016 study the authors also note that “up-regulation of β-catenin and noggin, along with the expression of TGF-β and SMAD and inhibition of BMP4 could be the mechanism behind this ectodermal differentiation and hair-like structure formation.”

University of Kansas Innovation and Collaboration (KUIC) Patent and Licensing Options?

The main author of the above studies is Dr. Omar Aljitawi who is currently a professor at the University of Kansas Medical Center. According to his bio “Dr. Aljitawi also has been studying Wharton’s jelly matrix as a scaffolding material for tissue regenerative applications like bone and cartilage regeneration.”  However, of much more importance is the fact that when it comes to hair regeneration, this technology might be for licensing or sale?!  I say this because of this page on the University of Kansas Innovation and Collaboration (KUIC)’s website.   Most relevant sentences/quotes on that page:

Application: Restore hair and treat baldness.

Benefits: The method can be used for restoring hair, which can potentially solve the problem of baldness.

Why it is Better: Current technology simply isolates cells from pre-existing hair shafts. This new method derives mesenchymal
stem cells from Wharton’s jelly matrix and stimulates them to produce hair follicle cells and hair structure. Hair
can be restored and baldness can be treated.

The inventors of this technology are listed as the earlier mentioned Dr. Omar Aljitawi along with a Dr. Lynda Bonewald (who seems mostly interested in bones and not hair).  The actual patent titled “Generating ck19-positive cells with hair-like structures from Wharton’s jelly” does not have Ms. Bonewald’s name on it.

The “licensing associate” for this technology is Dr. Aswini Betha.  I am curious why companies are not approaching him or the University of Kansas to acquire this technology considering that the patent was filed in 2013 and approved in 2014?  Perhaps Mr. Neal Walker would be interested?

The University of Kansas has now been added to the list of important hair loss cure research centers around the world.

Edit: There is also another 2014 study from India that suggests that human Wharton’s jelly mesenchymal stem cells promote scar-free skin wound healing with hair growth.

127 thoughts on “Wharton’s Jelly Derived Mesenchymal Stem Cells and Hair Follicle Generation”

  1. This is a great find! It remains to be seen how effective this might be but I would note that there is some similarity in the thought process between this and the fact that BioD Restore is beginning to be used in acell/prp procedures. The company that makes BioD Restore specializes in the development of products derived from placental tissue. You can read more about the company here: http://www.biodlogics.com/about-us I would also speculate that we might be able to put this in the potentially sooner rather than later category of possibilities since a product like BioD Restore (dervied from the placenta although apparently no where near as potent as Wharton Jelly) is already in use.

  2. Admin,

    How faithful are you in shiseido? Why arent people more faithful in the expected 2018 commercial release? I am not saying that one should be but are most people expecting this will be defunct?

    1. Hi Matt, most people who have followed the hair loss industry for the past 10 or more years have seen their hopes dashed numerous times. I am one of the most optimistic ones out there as you can tell by the title of my blog….I feel this time it will be different.

      I am very optimistic about both Japanese players — Tsuji and Shiseido. Tsuji more so than Shiseido.

      1. You are the third person who has directly accused me of lying to my readers….and one of those three was a fraud posting under many usernames (once even answering to himself and praising his own post while pretending to be a different person). In your case, here are the 6 INSIGHTFUL comments made to date on this blog from your IP address in the past year:

        1) Where there is life, there is hope!
        2) Haha. Nice joke. That day will never come…
        3) Lol you guys are so naive. This is bs….
        4) “Updates”
        5) No. We wont see a cure.
        6) Admin will always be optimistic in everything he post on this blog, or he would loose readers….

        You are clearly too intelligent for this blog, so I have to ban you or else you will make me lokk less intelligent.

        As an aside, it is impossible not to be an optimist when considering the past 6 months (read entire post below):


        1. Someone get @Christ some burn salve, good work @admin. Personally I don’t understand pessimists. In hope we can find some current happiness. Either way the outcome will be what it will be, might as well be as happy as possible until then!

  3. Well done admin, very interesting. On a side note. ” Bio Japan 9-15 October 2016A poster showing the latest results from Follicum will be presented at Asia’s Premier Partnering Event for the Global Biotechnology Industry.”

      1. Isn’t Follicum kind of an irrelevant player at this point? I mean, even if the science is sound, they are still in pre-clinical trials and experimenting on mice.

        There’s a 0 % chance they can get through clinical trials, raise funding and commercially release a product before Histogen, Replicel or even Tsuji at this point, correct?

          1. Sooo up till 2018 we have

            – Minoxidil!!
            – Minoxidil + Dermartrolling!!!
            – Finasteride and Spiro!
            – Dermabrasion ala Follica, but all your newly sprouted terminal hair will be gone in 6 months!! (according to phase2a only 2% increase in terminal hair at 6 month mark vs 12% at day 84 after treatment..yikes!.. but you get 100 new permanent vellus)
            -Dermabrasion ala Follica + minoxidil!! Maybe this way 9% of new terminals won’t dissapear so quickly and you’re good for 2 years
            -Kelopesia foreskin lotion from Turkey University!
            -Swisstemples special nazi coctail that did not do anything and he stopped posting new photos

            Ehh life’s hard for us baldies

          2. My mistake….they’re still in phase 1 though. Still observing efficacy in mice models, which actually doesn’t tell you anything since everything grows hair on mice.

            My opinion – 5 years is pipedream. And even if it isn’t, you going to spring for a topical minoxidil replacement when full-blown hair regeneration is here/ knocking at the door? Doubt it.

      2. Ah now this i can’t wait for. I think that Follicum will be the first thing which is more cure than treatment. Very excited for this post, will be watching blog like a hawk until its online!!

  4. I’m no scientists, but it seems that things have pretty much come together; and that there may in fact be, when all is said and done, multiple methods to cure this.

  5. Excellent research admin.. I wonder who will get it licensed 1st.. Heck I say go to shark tank Mr. Wonderful would love to have roberts hair:))))) he would pay top dollar

    1. Robert has had transplants! Check back to season 1 or whatever of “dragons Den” a Canadian show on CBC where it all started. He wasn’t kevin bald, but still…he was receding.

  6. Admin, may you please write something in the near future about SMP for a potential solution until the real cure is out? I think it will help a lot of us out till there is a cure but I’m afraid of long term side effects and potentially damaging the follicles as well.

    1. I don’t think SMP will damage follicles because I had it and it’s only on the surface of scalp. Anyways it’s temporary and will fade away in 5 years

    2. Considering Turkish doctors are now offering FUE package deals for less than €2,000 and giving good and consistent results, I’m wondering why tattoo artists in the UK are charging £3,000+ for a full SMP application which to be honest, looks nice when new and done properly, but isn’t real and could fade over time.

    3. Hi Johnny, I’ve had SMP done and there are no known side effects and I’m very happy with the results (though of course not as happy as when I had a full head of hair). There’s a whole forum discussing SMP specifically on the Skalp website (https://www.skalp.com/forums/forum/client-experiences/) with many users (pre and post treatment) posting stories and photos. I’m happy to answer any questions here. There have already been a few posts and comments around SMP on this blog and I think you can just search ‘SMP’ to browse.

  7. Aclaris updated their website, new pipeline including AGA. I did not listen to the webcast btw.

    Also Samumed’s Chief Scientific Officer, John Hood, as mentioned in several articles as being the brains behind the whole company has left Samumed last April, he is also removed from the company website.

  8. Please!
    Can someone help me with my language barrier here.
    I do not fully understand this approach. The whole success of this would be limited to those that had a sample of blood taken, when they were a baby? (from the umbilical cord).
    How can a grown up men profit from this?

    Differently put:
    Wharton’s jelly mesenchymal stem cells are the source of this treatment – but how would it be possible to get the Wharton’s jelly mesenchymal stem cells from a grown up man?

    Thank you in advance!

    1. JayjayAustria, excellent question and I was wondering the same thing and emailed them to see if they were using eyeball related Wharton’s jelly…most likely not, but then it could imply a cure only if you saved your umbilical cord which would be strange!

      1. @Admin thank you for responding!
        I originally thought about addressing you with this question – but assumed you would be very busy.

        I love your blog, keep up the good work!

        1. Hi JayjayAustria, see Dr. Aljitawi’s responses. I asked him to elaborate on third party MSCs.

          Everyone else please do not e-mail him! This technology is years away from being realized if at all for hair, but nevertheless it is fascinating to see the importance of the umbilical cord and umbilical cord blood. Perhaps in future any child whose umbilical cord jelly is saved will never bald?!

  9. Interesting stuff… Need to read over it again but it looks like it is worth some trials.

    Over on HLT they are going to post an interview that they did with Tsuji… They say tomorrow is when the translation is done but last time they took a couple of extra days to get the edits down. Exciting stuff.

  10. Wharton’s jelly is also present in the vitreous humor of the eyeball, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate).

    Do you have AGA + Eye Floaters?
    You have collagen and hyaluronic acid trouble, just like me.

    Do you have AGA + Seb Dermatitis?
    You have collagen and hyaluronic acid trouble, just like me.

    Let us know if you have a combination of certain conditions.

    1. I got Eye Floaters, AGA that I treat successfully with Fin/Minox (no more receding hairline) yet my overall hair density is getting lower and lower -> similar with my brother and father -> DUPA
      And DUPA is just the biggest pain in the ass, as no future treatment will be able to deal with it, it seems.

      1. “And DUPA is just the biggest pain in the ass, as no future treatment will be able to deal with it, it seems.”
        Where the hell did you get that information bro… don’t post b**s** like that please for crying out loud, people get scared when they see things like that written… How is DUPA and AGA not treatable in the same way?

        1. I really did not mean to scare anyone.
          As for DUPA, many experts on hair restoration expressed their doubt that DHT is the troublemaker for patients that suffer from DUPA. Dr. Robert M Bernstein compared DUPA to senile alopecia, a phenomenon that is poorly understood. This year however, he did share the same news that this blog’s admin also shared: http://www.hairlosscure2020.com/one-reason-hair-thins-is-because-some-of-it-turns-into-skin/

          So it seems that COL17A1 plays a role for DUPA and senile alopecia, but a cure for this hair loss condition seems not on the horizon. As for future treatments, the concept of Replicell is unlikely to alleviate the symptoms, Tsuji/Kycera etc. just as well because there is no safe donor area = basically playing roulette with a lot of money.
          That is why I expressed my unhappiness, which I usually never do! (…would never do in the real life, because there are, obviously, worse things and one would just look like a total loser talking about this in an attitude of self-pity)

          1. Having said that, the experts aroundTsuji, Riken definitely know a hell of a lot more than I do, so maybe they find a way to get a few healthy hairs.

            Either way I would be willing to play this kind of roulette if push comes to shove. 🙂

  11. With respect to the issue raised above about the possible need to save your umbilical cord for the potential of Wharton’s Jelly to able to be used, my understanding was that placental tissue was immune privileged: Here is a quote from the Biodlogics website: “Our research and development efforts are focused on the regenerative potential of amnion and the other placental tissues given their unique biologic structure, their rich source of undifferentiated stem cells, and the unique immune privilege that characterizes their function in the body.” This raises the question of whether Wharton’s Jelly is technically placental or amniotic tissue, but I did a google search on Wharton’s Jelly and quickly found this quote: “Likewise, their rate of proliferation, immune privileged status, lack of ethical concerns, nontumorigenic properties make them ideal for both autologous and allogeneic use in regenerative medicine applications.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377382/

  12. Latest update from Follicum on their website: Have completed formulation work and started phase 2A work for next 3 months for testing efficacy of FOL-005. This is looking very sincere and promising and should give us hope.

  13. HUGE NEWS!

    Aclaris – the company with the JAK Inhibitor testing of both Oral and Lotion for AA type hair loss (that has been in pre-clinical for 9 months).

    The just added Adrogenic Alopecia testing of JAK inhibitors at the Pre-clinical level (at the same time line level where they have been testing JAK Inhibitors for AA type hair loss for both Oral and Creme).

    i.e.. even though AA testing has been going on for 9 months they put the testing for AGA at the same time position in the Pipeline.

    Wow! They are officially testing JAK for AGA type hair loss. Its in their pipeline.

  14. http://www.aclaristx.com/pipeline

    Here is the HUGE News (sorry Trump). See link above. The item in the pipeline 5003 is the test for Normal Male Pattern Hair Loss.

    What a Year!!!! From absolutely no hope to officially testing a possible 100% treatment where you get your own Natural Hair.

    I say I have been right for the past 2 Years. JAK Inhibitors is going to be the best thing we have for the next 20 years. Lets just hope that it works as well for AGA as it does for AA type hair loss.

  15. HUGE NEWS!!!!!!!!!!!!!!!

    HUGE NEWS!!!!!!!!!!!!!!!

    HUGE NEWS!!!!!!!!!!!!!!!

    See posts above.

    We have OFFICIAL testing of a possible 100% treatment for Normal Pattern Hair loss.

  16. In the pipeline, they skipped the Research Section and stuck 500003 (testing for AGA treatment) at the same level as the testing they have been doing for AA treatment even though the AA treatment they have been doing for almost 9 months).

    Wow. Wow! Wow!!!!!

  17. Instead of Official Testing I should have said The Official Start of Commercialization of a cure for AGA by a for Profit Public Company and they do not spend money unless they expect a profit.

    Wow. What a morning. I have been going to the Aclaris website everyday just wondering if they were going to add testing of JAK for AGA and they finally did. They do not put it in a path for commercialization unless they have reasonable proof that it works.

  18. The company must be piggybacking their research on AA type hair loss cure with AGA type hair loss cure. That is why 50003 pipeline number for aga hair loss treatment was placed in the same position as AA type hair loss treatment even though AA research has been going on for 9 months. Thus we are starting out 9 months ahead from where they normally start their research timeline.

    Good news. All is good news today. AGA hair loss suffers had no possible treatment and now one is on a path to commercialization by a public company. We are on our way.

  19. Forget the comb over type “treatments” due out in a few years.

    We finally have the real deal, at least proven for AA type hair loss. We are on our way. Finally!!!!!!!!!!!!

  20. I always hated hearing about the Stem Cell type cures that are 20 years out, at least. Or the fuzzy picture type cures OR the Histogen type cure where you cannot tell the difference. Or, the this is being researched in the lab and if everything goes right we will have a possible cure even though we do not know how well it will work and then we can put it on a path to commercializaiton after that. In other words NO HOPE. Well we have hope now. Lots, and lots of Hope.

    1. I think you need to calm down. There is currently zero proof that a drug that works for AA can just be pivoted to work for AGA given how differently they work.

      That’s number one. Secondly, this is still in pre-clinical trials. I’m almost never the debbie-downer pessimist on these forums but do you have any clue what that means for this product’s timeline assuming it ever makes it to commercialization, which is a BIG if? We’re talking 7-8 years minimum. If there aren’t better treatments available in 7-8 years like Replicel and Tsuji, I will have long accepted my fate, not to mention lost so much more hair I’m effectively a cue ball.

      1. You do not know much about the JAK Inhibitors. They are ALREADY FDA approved and 7-8 years is ridiculous.

        Look at the Timeline Graph. It almost has the AGA JAK Inhibitor at The Phase I trial. They have been working on in Pre-Clinical the AA Inhibitor and it looks like they fast tracked AGA Inhibitor to match the same TimeLine as the AA Inhibitor.

        Lastly, I guess they did not bother to try and experiment to see if it works for AGA (note it shows in the timeline it going right through the Research and most of Pre-Clinical Trial). This public company is just going to experiment out of the blue and spend millions of dollars in testing AGA Inhibitor without ever bother trying it to see if it will actually work.

  21. i dream of a total reversal of AGA such as seen in the AA cases on JAK…

    the “alopeciaexperiment” insta account from zero to a full head of thick hair…. immagine this happening to us… no hair transplants, no injections, only a topical which could reverse all damage done by AGA…. the jak dream currently on a mouse model

    1. It is not on a Mouse Model. Look at the Pipeline. They are almost ready to start trials on HUMAN!!!!!!

      Probably less than 3 months to human trails, just a guess by how close they have it to Phase I.

      This is Grand News. The first time ever that a real 100% proven to gain all of a person’s hair back (in AA type hair loss) that is about to be tried on HUMANS, just months away.

      Just great news.

  22. Someone walks up to me 3 years from now and asks what is male pattern baldness? Me, I have no idea look I have All of my own natural hair.

  23. NASA to say you are excited is an understatement…id like to know when you honestly believe jak will be available on store shelves to treat mpb??

    1. Dr. Christiano once said about 4-5 years (I know famous words) about 1 year ago. Thus 3-4 years.

      But it looks like they already fast tracked it. As i mentioned they put the AGA treatment at the same place on the Timeline as they did the treatment for AA even though they have been doing it for 9 months on AA. And I think if it is proven to work they will through money at it fast to speed everything up ASAP and they might be doing that now as it appears it has been moved up the timeline.

      Also note: the drug is ALREADY FDA approved the formula is just being tweaked. Plus, this is a 1/2 billion marke cap company, big company. They have it on a Path to Commercialization. This is not well we will save our umbilical chord cells type unrealistic treatment. This is the real thing.

      The first time ever that a 100% PROVEN hair treatment has been put on a commercial path in a public company for AGA.

      What is a better option for you. Waiting for the Umbilical research to pan out OR the about to start Phase I trials on HUMANS for 100% hair return for AGA, given that it already has worked on AA type hair loss.

      1. hell ya nasa high 5
        just saw it in pipeline – i bet your happy
        wonder how long the phases will take considering it grew in less than one month in mice etc

        1. My guess they start within 3 months Human Trials. You can see that ATI-50003 is almost at ready for Phase I trials. Simply Amazing. We are almost there. Just hope they release photos after phase I.

          1. I’m not sure about it starting trials in 3 months but, HLT has a conference call next week with Alcaris. Dr. Christiano will be present on the call as well!

            everyone should keep their optimism in check until we get official word from the Alcaris

  24. I’m optimistic about JAK, but the only thing that kind of worries me about it is the fact that Christiano has recently started a stem cell based hair regeneration startup (Repunzel) in order to tackle alopecia. Why would she do this if JAKs were, in fact, the cure?

    The only reason I can think of as to why she would do this is that she (like many others) are trying to develop a one stop cure all. As in you go get a treatment once, and that is it. As opposed to JAK which is a continued treatment that you have to use multiple times a week.

    1. So let’s say that topical JAK is successful both against AA/AGA and makes her insanely rich. With Rapunzel and stem cells and loads of money maybe she hopes to find a way for as you stated a “cure” (in its true meaning) and also with stem cells find a way to put more hair on the head so women with thin hair can get thick lush mop of a head hair.

  25. Some pretty big news just dropped on HLT about Riken/Kyocera. Although the full interview is not yet ready to be published (still in the translation and editing process), the Admin over there has given a small teaser. Here is a direct quote from the HLT Admin regarding Tsuji’s work:

    “Just had a conversation with the translator, and have some preliminary information for you all from the interview. She mentioned that in the interview they stated they *are* able to control the width of the resulting hairs, as well as the color. And … the density (# of hairs) in a given area.”

    Here is a direct quote from Riken about the final challenge they are facing:

    “The development of the technology to cultivate mesenchymal stem cells, that is papilla cells, which can be applied to human clinical trials, is currently in progress. However, as for epithelial stem cells, it still globally remains as a significant challenge. We are currently still in the middle of the research and development portion of this project, but we have optimistic news: Based on our recent research results, we finally have some prospects to resolve this issue soon.”

    TLDR: Tsuji’s method can control hair shaft width, color, and density. Tsuji and his team believe they are on the cusp of overcoming the single largest hurdle in the hairloss industry (successfully culturing epithelial cells). This is pretty big news.

  26. Stopping by to thank @admin once again for all the great work hes doing, and to say heyyyyy to @nasa_rs for giving a heads up about Aclaris putting JAK AGA treatment on their pipeline graph! Ohhh yeah baby<3

  27. Nice news @Red.

    We are Finally getting someplace in this war against hair loss. It actually seems like we are almost across the finish line. There is now finally REAL treatments soon to become available.

  28. Take a Good look at ATI-50003 (see link below). There it is in the Pipeline of a large Pharmaceutical company a newly listed treatment for male pattern baldness that will probably make this dreaded disease a thing of the past. Finally, finally Human trials are about to start probably within 3 months.


    1. this is good….but I wouldn’t say “large”. I read a short (as in short the stock) thesis on Aclaris because their main drug was just potent hydrogen peroxide…still, hope something comes out of JAK for hairloss. There are many possible treatments that could be better than min. But most of us will be fully bald by then so likely won’t give us a cosmetically significant improvement. Hope Follicum, Brotzu or JAK come out soon though if they work..or Histogen or Replicel, but those have been around saying they were close since I was a teen…

      1. Remember JAK Inhibitors have been PROVEN to regrow 100% hair in at least some AA type hair loss patients. Like I said, if JAK Inhibitors do not work more than likely there will not be anything else for another 20 years. I would rather have JAK Inhibitors work and I am NOT going to down play the strong possibility that this will work 100% and be available within 3 years. Look at the timeline it is almost in Phase 1. And this is already an FDA approved drug. I think they just tweaked the formula a bit.

  29. i like ur enthusiasm nasa, i remember the ceo of aclaris who said that his colleagues are trying topical jak for aga on their heads and the results seem “interesting”

    william any update on ur 30 % tofa use ?

      1. I can vouch for these claims. Neal Walker said in a presentation sometime around May/June that although oral JAK inhibitors do not work for AGA, topical JAKs do, in fact, work for AGA. He also added that the results of topical JAK inhibitors in AGA patients were “very interesting”.

        We are only waiting for confirmation on what exactly the claims of “does work” and “intersting” mean.

  30. Hey Red you said –
    Tsuji and his team believe they are on the cusp of overcoming the single largest hurdle in the hairloss industry (successfully culturing epithelial cells). This is pretty big

    That’s already been done in January 2015…


    Hopefully science isn’t being halted by IP patent registry b.s. If RIKEN and Terskikh aren’t aware of each other’s work they should negotiate merging technology right about now and stop wasting time for everyone involved including themselves.

    1. egghead – soon you will have to change your name to Not An Egghead as I strongly believe JAK Inhibitors are going to work. We are almost in Phase I then we will officially know.

  31. JAK Inhibitors are officially in the Pipeline (and were fast tracked since they match the AA Inhibitor timeline). This is it. Phase I starting soon. A $500 million market capitalization public company has JAK Inhibitor in the Pipeline past the Research Section, and almost past the Pre Clinical Section and almost into Phase I all for a potential 100% treatment for AGA. We all have been waiting too long.

    This Is It The Moment of Truth in about 3 Months. Drum roll please…

  32. A product that has been proven to regrow 100% hair in AA that is about to be in Phase I trial for AGA from a large public company is worth much more than 1,000’s of potential cures in the lab.

  33. nasa_rs:

    Do you think this treatment will be effective for BIG alopecias (DUPA / Total diffuse with miniaturisation / Egghead / Medicinal diffuse alopecia because Prozac, Risperidone and others sh*t) ???

    1. They have different JAK Inhibitors, 1, Ii, Iii. Each is slightly different. They would not be getting ready for phase I trials if they did not have strong reason to believe that it would work.

  34. In regard to JAK, Red made a good point.
    Dr. Christiano is working on other ways to combat HL.
    She may have seen some potential in JAK but obviously wasn’t enough to stick with it and keep pursuing.
    I hope Aclaris has found something Christiano missed.

    1. Or she sold it to fund the research she is doing now which is the next step in hair loss treatment, permanent results from injections. I think she is still involved with JAKs, she’ll be on the conference call next week with the admin of HLT.

  35. Aclaris already stated it works for AGA. Not sure where all the confusion and loss of interest is. It works period why would they say it does if it doesn’t.

  36. hlscc:

    No, I try Tofac 50mg+DMSO since 6th july 2016 but vehicule was very bad. I stopped the my amateur treatment after just 2 month because dosage, mix, conservation, ingrédients, etc. are not good.


    I want to try the Tofac cream of Chemistry Rx Philadelphia:

    But they want not to deliever the cream to Québec (Canada) and I need a prescription by a US dermatologist only. It’s very complicated for me.

    Are there a trusted person here who would like to contact me privately to help me get the cream? A person living in the United States near Philadelphia, which would fetch a prescription from a US dermatologist , who would run the Chemistry Rx buy the cream. Of course , I will refund the price of cream and the delivery Philadelphia-Québec.

    Thank you.


    I have a really BIG alopecia. Nasa, if you can ask at this question, thank you

    Do you think this treatment (Aclaris Inhibitors JAK in pre-clinical) will be effective for BIG alopecias (DUPA / Total diffuse with miniaturisation / Egghead / Medicinal diffuse alopecia because Prozac, Risperidone and others sh*t) ???

  37. @egghead that is an interesting article, however I’m unsure if dr. Terskikh was using successfully cultured and multiplied epithelial cells in his research, or simply just immediately extracted epithelial cells. The biggest problem right now in the hairloss industry is that, with current methods, it is not yet possible to successfully culture and multiply epithelial cells. When culturing and multiplying these types of cells, the gene expression in these cells appears to be lost in the culturing process.

    If Dr. Terskikh was able to successfully maintain gene expression through the multiplication of epithelial cells, that is definitely impressive. The article is unclear however. I believe Dr. Tsuji and his team will overcome this hurdle within the next couple of years. I wouldn’t be surprised if being on the cusp of solving this problem was one of the reasons why Kyocera was so eager to partner up with Riken. I find it hard to believe that such a partnership would be formed if there were no realistic potential solutions to such a large problem.

    Also @ nasa_rs, although I am optimistic about Aclaris and JAK being a good treatment for hairloss, if it does end up failing, I don’t believe we are doomed for another 20 years. The Riken/Kyocera partnership is without a doubt the most promising venture in the hairloss industry to date. I think it is safe to say that if they can solve the problem of epithelial cell culturing and multiplication, then they should quite easily bring a 100% one stop cure to hairloss withing 8-10 years at the absolute latest. 2020 being the absolute best case scenario. JAK being successful would be groundbreaking, but if it unfortunately does not pan out for whatever reason, there is still much hope.

    1. that’s not the only article written, I emailed the University’s hair follicle department that discovered that the same week they were concerned with who I was in regards to protecting their IP. I didn’t get any information from them because of that reason. You should read more into what I showed you because i’m about 99% sure It’s exactly what it implies. Their looking for investors to make it a product right now… that say’s something.

      1. That is very interesting. Thanks for the info egghead. If they have been successful at overcoming this large hurdle, then that is seriously groundbreaking.

        I’m looking forward to hearing more about this.

  38. I have no interest in the whole JAK therapy. You guys are crazy. You’re playing with the immune system and who knows what are the consequence. Growing hairs together with cancer is not all you want, even Fin that brings sides have been blamed for long. I won’t count JAK as a potential treatment given that we will probably have Replicel, Histogen, Follica and Tsuiji, or Brotzu lotion and Pilofocus if we are lucky. I’m not hyped about this at all,

    1. Worrd. Don’t think JAK will have 0 consequences. Also sure it will be prohibitively expensive. Any approach to hair loss which fundamentally changes a systematic process is playing with fire. A topical which remains localised, i’ll jump at…screwing with hormones or immune system…you’re taking a huge risk

    2. Scratch out Replicel have you seen their stock price? Talk about a Penny stock. Aclaris, the stock for JAK, is up 20% over the past ~week and it has a $500 million market cap company. Doubt they want to be sued by us for billions.

      I’ll take my chances with a Lotion treatment. Like Evel Knievel you got to live in order to have a life. I like that expression and I just made it up.

  39. Nasa_rs… i’m thinking you haven’t dealt with hairloss for as many years as others. so many years with so many letdowns for me so it’s hard to jump on the bandwagon.
    i’ve been throwing everything i can to keep my hair and nothing is working anymore and my time is up.. if this takes a year or more then i won’t have much to save anyway.
    we’ll see i guess, not holding breath..

    1. Unfortunately I have. But in my case it is like the Last Huraah. It is this or absolutely nothing. Now you know why I am gunge ho about it at all cost.

      It is JAK, let this finally be it. It only makes sense as we know it works for AA type hair loss 100% hair returned in (I believe most) cases.

      Note: I guess I will be on this board much more now that it is just a short (my guess but I can’t be that far off since it shows it 90% through Pre Clinical area) short 3 months until it enters Phase I.


      1. I’m hoping for positive JAK news next week, they may even announce when the first trial will commence. If this can restore lost hair JAKs plus replicel will be a go to cure if Tsuji’s team aren’t successful. But I think they will be

  40. Hi Admin,

    Just thought you may like to hear the Italian gentleman from Rivoluzione blog spot just posted photo of 1st 100 bottles compounded to work like Brotzu for group buy……..the link is …..


    hope it works because I contact a friend who works in a compounding pharmacy and he said between the expensive price involved and the fact that his people could only keep it stable for up to ten days I have decided to wait for further news.

    Best wishes R. Ron

  41. Do you guys think that those possible cure will also help those with diffuse thinning instead of a classic patterned long lasting alopecia? I lost nearly everything in less than 3 years how can that be cured? I hope the same way they’re going to cure AGA

  42. According to HLT, the Tsuji crew is still planning for human trials to begin in 2018 and commercial availability still on track for 2020.

  43. As somebody who has been NW6 since 24 (now 30), what hope is there for me on the horizon? Will any of these touted cures help somebody who’s already lost theirs?

    I keep seeing terms like JAK, Kyocera, Replicel, tofac, etc., thrown around and it’s hard to decipher the legit substantive developments from the no hopes.

    1. The Riken/Kyocera treatment, if successful (which looks pretty likely that it will be) will be able to give you your hair back regardless of what Norwood you are. With this treatment a NW7 would be able to return back to a NW1.

      The process that they are using mimics you’re bodies own pe-birth processes which created your hair follicles while you were still in the womb. They do this by extracting a small biopsy from the back of your scalp, they then culture and multiply the mesenchymal and epithelial cells from that biopsy. These cells are then “mixed” with one another to form something called “hair follicle germs”. These germs are then reinjected into your scalp, which soon form brand new fully functional hair follicles.

      The treatment is on schedule for human trials in 2018, and still on schedule for commercial release in 2020 (a little more than 3 years away now). This is effectively a full on cure, as it has been confirmed that hair colour, density, and even individual hair shaft thickness can be controlled. Nobody would ever have the slightest clue that you were once bald.

        1. Hi @JayjayAustria. From what I have read about the procedure (and in hairloss in general), I believe that as long as there is an area on the scalp where Mesenchymal cells and Epithelial cells can be extracted via biopsy, then this treatment should, in theory, work even for patients with DUPA.

          Keep in mind that the treatment proposes the formation of entirely new follicles. The brand new follicles will produce hair that will be healthy and strong, since the hairs are growing out of newly formed follicles. The effects of DHT (and other biological processes relating to balding) will eventually return to act on these hairs however. Despite this, you should be able to protect these new hairs with Fin/Minox, or preferably a new treatment like Histogen and/or Replicel.

          At worst I would say you would need to go for “top up” treatments as the years pass and more of you’re original hair needs to be replaced by new “Tsuji-hair”.

          So to answer you’re question, I do believe it will be possible for a DUPA sufferer to get a great head of hair with this treatment, but that it will likely take continued maintenance and top ups to uphold the good results.

  44. Hey guys, tomorrow hlt is going to do an interview with aclaris, they’re currently collecting the questions that are going to be asked, if anyone has any questions now would be a good time to ask!

  45. Not sure until when you can post questions but they are going to be giving Aclaris + Christiano a call tomorrow regarding Jak’s over at HLT. If you have a question, there is a thread where you can post it.

    Nasa… we are looking at you.

  46. Although this Aclaris stuff is interesting. I’m starting to be more interested by Tsuiji. It sounds really ideal, but is this actually growing hairs in the lab or just reinjecting the matrix of cells necessary back into the scalp?

    I think if it’s the latter it sounds perfect. You could essentially go in for collection, come back and get a procedure that i image is like a tattoo session. Grafting the germ back into the scalp.. boom 14 days later hair starts growing..

      1. I’d only glanced at it before, but that sounds pretty ideal. I guess it would be a matter of replicating the process globally so the treatment isn’t only available in Japan.

  47. Admin,

    Do you agree that shieshdo (forgive the mispelling, too lazy to look it up) will have more of an impact on people who have minimal hairloss vs those who have extensive balding? For instance, i used a chemical (relaxer) on my scalp and i have little spots by my kneck and side burns that did not grow back. Im not trying to sound individually biased based but I would think I would be one of the ones in luck. I also have no dht problem as my genetics are hair proned and will not lose hair due to AGA once a method that works comes into place

  48. I apologize if this question has been asked, but the third-party collection referenced is from what tissue source: adult, live births, embryonic stem cells? The source and controls regarding material collection doesn’t seem to have been answered when you made your inquiry. Obviously, this would be an issue for many future consumers.

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