UCLA vs USC in the Hair Loss World

University of California Los Angeles (UCLA) and University of Southern California (USC) are both based in Los Angeles, California in the USA. They have one of the most intense and historic rivalries in American college sports, especially in American football. The two campuses are separated by just 12 miles. In an amazing coincidence, the two most important hair loss research related discoveries in the world this month came out of these very two universities.

UCLA scientists find two new ways to activate hair follicle stem cells

For our purposes, the UCLA findings (published just today) seem to have the greatest significance. Scientists (led by Heather Christofk and William Lowry) have found two drugs that activate hair follicle stem cells in mice. Interestingly, both drugs are topical, and one (RCGD423) involves activating the JAK-STAT signaling pathway. No idea if this drug is connected to JAK inhibitors in any way, but that acronym keeps coming up regularly these days.

Both drugs involve increasing lactate production. Apparently, lactate production is strongly connected to hair follicle stem cell activation and hair cycling. In their initial research, the UCLA scientists blocked lactate production genetically in mice and found that this prevented hair follicle stem cell activation. Thereafter, they found that increasing lactate production genetically in mice accelerated hair follicle stem cell activation and increased the hair cycle.

RCGD423

The first drug, RCGD423, activates the JAK-STAT signaling pathway, which in turn leads to an increase in the production of lactate. This then activates hair follicle stem cells and also leads to quicker hair growth. UCLA holds the original patent for RCGD423, related to its ability to rejuvenate cartilage, and has filed a provisional patent for its use for hair growth purposes.

UK5099

The second drug, UK5099, blocks pyruvate (a glucose metabolite) from entering cell mitochondria. Interestingly, this forces an increase in the production of lactate in the hair follicle stem cells and therefore accelerates hair growth. UCLA has filed a provisional patent for using UK5099 for hair growth purposes.

Perhaps the most interesting quote from the earlier linked article summarizing these findings is: “I think we’ve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general“. On this blog, I have covered the connection between fat cells (adipose tissue) and hair growth numerous times due to significant recent research in that area. So I am not surprised at all that metabolism is also important when it comes to hair growth.

It is, however, surprising that hair loss research has uncovered so many new distinct pathways and mechanisms in the past few years. All of these are unrelated to the tried and tested method of targeting dihydrotestosterone (DHT) reduction. This is great news, since we already know that even close to 100 percent reduction in DHT will not bring back long-lost hair for most people, plus often comes with side effects.

USC scientists restore hair generation in defunct adult cells

A team of scientists from USC (led by Dr. Mingxing Lei, with collaboration from others in China and the UK) have managed to restore hair regeneration properties in adult mice cells that had stopped growing hair. A non-scientist friendlier summary of this work can be found here. One of the co-authors of this paper is Dr. Cheng-Ming Chuong, who I covered on this blog before.

Using intensive video analysis and documentation, bioinformatics, and molecular screenings, the scientists figured out a:

Molecular “how to” guide for driving individual skin cells to self-organize into organoids that can produce hair.

Also:

In the future, this work can inspire a strategy for stimulating hair growth in patients with conditions ranging from alopecia to baldness.

Very unlikely to come to fruition anytime soon of course, but considering that some of the research collaborators are from China… perhaps things may move faster than I am guessing if they could shift their research and potential clinical trials to that country?

Yet More Indian Studies Involving Microneedling

Dr. Rachita Dhurat

In late July, user “Saleen” commented that Follica had updated their website yet again. This time, they added several clinical advisers on their “our team” section, including the well known Dr. Rachita Dhurat. The reason this Indian doctor is well known is because of her groundbreaking 2013 study (with extensive before and after photos) titled: “A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study“. In that study, she used a dermaroller of 1.5 mm sized needles (plus minoxidil) on 50 patients, and 41 of those patients showed a very favorable outcome. In the minoxidil only comparison group, just 2 of 50 patients saw similar results.

Moreover, in 2015, Dr. Dhurat published a second related study (albeit with a much smaller sample size of 4 patients), that found that microneedling led to new hair follicle growth in all patients. Moreover, none of these patients responded well to conventional therapy in and of itself (i.e., finasteride and minoxidil).

A number of extremely renowned US based scientists such as Dr. George Cotsarelis (University of Pennsylvania), Dr. Luis Garza (Johns Hopkins University) and Dr. Maksim Plikus (University of California Irvine) have undertaken research on microneedling and/or wound-induced hair follicle neogenesis and published detailed reports that I have covered on this blog before. These scientists have received coverage in dozens of popular magazines in recent years. Nevertheless, for some reason, India based Dr. Dhurat is getting almost as much respect on this subject lately despite not having the same world leading university backing and related resources that the above scientists have (nor any popular magazine articles written about her). Hopefully, fewer resources does not mean weaker research.

More Microneedling and Hair Growth Studies from India

When excluding Follica related discussion (e.g., this from “noisette” on HLT), microneedling has not been getting much coverage on hair loss forums in recent years. It used to in the past, as evidenced by one of my earliest post on this blog related to the dermarolling fad.

On the other hand, several new studies related to microneedling and hair growth have been published in India this year.

  • In January 2017, Indian scientists published a report in which they found that patients being treated with microneedling plus minoxidil plus PRP saw superior results in comparison to patients being treated with minoxidil alone.
  • And last week, scientists in India published a study in which they found PRP plus microneedling led to very favorable results when it comes to hair growth. Blurry before and after photos are in here (click on “preview article”) in case you can not access the full study via other means such as Sci-Hub.

Obviously the above two studies cannot be compared to Dr. Dhurat’s earlier work in terms of importance. Nevertheless, I find it surprising that scientists in the western world and Japan have not been focusing on microneedling and hair growth at all lately.

Side Note

One of Follica’s other newly added advisers has several videos on youtube discussing microneedling. See Dermapen review and here.

A Hair Loss Blog