Update: In 2015, Dutasteride was approved in Japan to treat hair loss. Moreover it was approved in South Korea even earlier in around 2010 it seems (no wonder some of the main studies involving Dutasteride and hair growth in men come from that country)! So now I think there is a very good chance that the same will happen in the US and EU in 2016.
Dutasteride (brand name Avodart) was approved in the US in 2002 to treat benign prostate hyperplasia (BPH — aka prostate enlargement in men). Around that time, Dr. Marty Sawaya became the most discussed and popular person on hair loss forums due to her stunning conclusions about the excellent results she had witnessed on people who used the drug to combat hair loss. These results were significantly superior to Finasteride. Dr. Sawaya even appeared on The Bald Truth radio show and gave a number of interviews to hair loss related websites in the early 2000s. It seemed like hair loss was essentially going to be cured via a medication. Besides stopping hair loss, Dutasteride also seemed to grow back hair that was thought to have become permanently vellus and miniaturized. A real miracle drug that inhibited almost all dihydrotestosterone (DHT) in the body, as well as both Type 1 5AR and Type 2 5AR (Finasteride only inhibited Type 2 5AR).
Dr. Sawaya’s most famous patient was was Dr. Monahan, and this interview with him on Hairsite is very good.
Unfortunately, Dutasteride’s manufacturer GlaxoSmithKline did not seriously attempt to get final Phase III FDA approval for its use as a hair loss medication. At the time, Dr. Sawaya gave some interesting reasons behind Glaxo’s decision to suspend the final phase III approval process. The main reason given was that based on annual sales of Propecia (Finasteride) and Rogaine (Minoxidil) at the time, it was unlikely that Dutasteride would ever become a blockbuster drug with sales of over $500 million.
However, recently, Glaxo has become serious about pursuing the final approval process. Here is an interesting recent thread to follow on Reddit regarding Glaxo’s pursuing phase III FDA approval for treating hair loss with Dutasteride.
Dutasteride 0.5mg/day clinical trial for final FDA approval — started in April 2013 and is expected to be completed in October 2014
Unfortunately, most hair loss forum members who have been using Dutasteride over the past decade do not seem to have seen stunning results based on anecdotal evidence. It is nevertheless likely that on average, the reported results on the forums have been superior to those attained from Finasteride as the various studies have predicted. Once Dutasteride (Avodart) is approved as a hair loss drug, there will hopefully be many more forum members taking the drug, and we will therefore have far more data points to compare results relative to Finasteride.
Will Dr. Sawaya be proved correct after all in her optimism regarding Dutasteride being a miracle drug? Will we finally see a third non-surgical FDA approved hair loss treatment option after Finasteride and Minoxidil by the end of 2015?