Category Archives: Osman Kibar

Brief Items of Interest, October 2016

Hair loss news first:

Update: A day after I wrote this post, CNN covered JAK inhibitors in a new article (in a pleasant surprise, they also looked at the androgenetic alopecia — AGA — angle).  Usually, all these articles on JAK inhibitors only look at alopecia areata (AA).  Yet again, Dr. Christiano says she is optimistic that JAKs could work on AGA patients (but only in a topical form).  Dr. Brett King is not optimistic, but he is still testing it out (in a lotion form) on his AA patients (probably the ones who also have AGA).  In the above article, the one AA patient who they show with regrown hair after being on oral JAK inhibitors did not regrow hair that he lost to AGA, although it is impossible to tell whether he did not regrow 100 percent of his AGA hair loss or not.  In any event, we will only know for sure about this once they test topical JAK inhibitors out so people should not get so emotional about this subject each time there are new developments.  You should also not try to test your own topical version as even the experts are having a hard time developing the appropriate version.  According to Dr. Christiano:

“Though she thinks men might have the same success with an ointment, she said the trick is that it has to penetrate properly. Compared with the paper-thin skin of mice, human skin is “much thicker, and it’s oily, and it’s deep, and it’s got a fat layer — so there’s a lot to think about when making a good topical formula.”

It is well worth watching the video in the above article just to see the funky haired mice.

— In a first, myself as well as all of this blog’s commentators missed the important International Society of Hair Restoration Surgery (ISHRS)’s 24th Annual Congress that ran from September 28th through October 1st in Las Vegas.  I did not even see any threads on the conference in any of the hair loss forums out there, which is strange.  I usually cover the 2-3 most important hair loss related conferences in the world every year in separate posts, but this time I forgot to do so.  You can find the detailed ISHRS 24th Congress final program guide here.  As usual, there were way too many interesting presentations.  For our purposes, the most important ones were:

  • Dr. Angela Christiano: “JAK Inhibitors, Hair Regeneration and
    Genetic Testing”.
  • Dr. Pantelis Rompolas: “Potency and Contribution of Stem Cells to Hair Follicle Regeneration”.
  • Dr. Rodney Sinclair: “Advancing our Understanding of the Biology of Androgenetic Alopecia and Changing the way we use Minoxidil to Treat it”.
  • Dr. Angela Christiano and Dr. Ken Washenik led a discussion titled “Biotechnology in Hair Regeneration”.

On Twitter, Dr. Alan Bauman told me that while Dr. Christiano did not provide any data on JAK inhibitors for androgenetic alopecia (AGA), she did hint that JAK inhibitors seem to stimulate the anagen phase of the hair growth cycle.  Fingers crossed as usual when it comes to this subject.  I was surprised at the number of presentations on body hair transplants (BHT), with Dr. Arvind Poswal discussing long-term ten-year plus results of his BHT patients.  Also surprising were the number of presentations on platelet-rich plasma (PRP).

— In stark contrast to the above omission, in the past week at least 10 (!) people either commented under a blog post or e-mailed me about cosmetics behemoth L’oréal (France) and Poietis (France) partnering to bioprint hair follicles via laser. This news item was extremely well covered across the global media and there are hundreds of articles on the internet about this interesting subject matter.  The end goal “holy grail” of this research will be to implant the new hair follicles into balding regions.  Below is the official company video outlining the technology and the goals behind this partnership:

— Unfortunately, it seems like Replicel has not fulfilled the contractual obligations of its partnership with Shiseido (although the former disputes this allegation).  In any event, it is unlikely that this will stop Shiseido from proceeding with its plans.

Cassiopeia (Italy) updates us on its topical anti-androgen product Breezula (formerly called CB-03-01).  Also see my past post on this subject.  It seems like even if phase 2 and phase 3 clinical trials succeed, this product will not come to market before 2021.

— Samumed’s Dr. Osman Kibar’s presentation (a small part of it is on hair loss) at a recent conference organized by the UK’s Royal Society of Medicine.  He received many compliments on Twitter for his presentation.

Cellmid has better than expected quarterly sales of its FGF5 inhibiting product Evolis in Australia.

Kerastem completes enrollment in Phase 2 clinical trials.

— Former baseball great Jose Canseco just announced today that he will get a hair transplant with Dr. Parsa Mohebi next week.

— Sportscaster Joe Buck’s hair transplant addiction nearly cost him his voice and his career.

The benefits of going bald.  I would much rather have none of those benefits and hair instead:-)

Men’s vanity involves hair transplants.

And now on to medical items of interest:

— The National Geographic is a highly reputable magazine so I believe them when they say that ending blindness is no longer just a dream.

Rapamycin could make your dog (and maybe humans too) live longer.

Microsoft aims to cure cancer in ten years.  In the end it is just a programming error.

— A very interesting new endeavor: “Human Cell Atlas project aims to map the human body’s 35 trillion cells“.

Teeth regeneration advances.

Building a bionic spine.

3D printing continues to revolutionize the field of prosthetic limbs.

First “three person baby” born in Mexico (doctors went there from the USA so as to escape strict regulations).  Baby’s parents were Jordanian.  Medicine will hopefully soon become very multinational.

Stem cells regenerate damaged monkey heart.

— Yet more evidence that turmeric is very good for you, but only when added to food that is then cooked.

Endurance training causes positive genetic changes.

— Not sure if I believe half the stuff in the below video, but it is well presented with 100 percent thumbs up likes thus far: K. Comella: “Reversing Aging with Stem Cells”:

Brief Items of Interest, April 2016

Hair loss news first:

— We start with Samumed and its Turkish CEO Osman Kibar being featured in a Forbes magazine cover page story and article that everyone was talking about last week. Turkish media also picked up on the story.  I did not realize that Mr. Kibar was such a good poker player (I do not agree at all with some hair loss forum members who have said that winning and placing second in his first two tournaments is just luck, especially when considering that the second tournament had 3,000 participants). More importantly, I did not know that Samumed is potentially valued at $12 billion (so Mr. Kibar is worth $4 billion with his one-third ownership stake), an unreal number for a company with somewhat unproven products and potential.  Further proof that the biotech sector is extremely overvalued.  As far as Samumed’s SM04554 hair loss product goes, the article does not divulge anything new that would raise my optimism level above what I gauged in my last post on the subject.

— Two weeks after I write the most sarcastic and innuendo filled post that I have ever written on this blog, the main subject matter in that post actually makes what seems to be a logical and wise move! Thorn Medical bought a majority stake in Okyanos Holding, the leading stem cell therapy center in the Bahamas.  In that sarcastic post from two weeks ago, I pegged Okyanos as being legitimate.  Note that Dr. Irum Khan’s previously subpar website has now also been revamped with some additional information on how she adds stem cells during a FUE hair transplant procedure.

— Two important studies were published in Japan in the past several weeks.  One on the never-before-heard-by-any-normal-human-being topical penta-peptide Gly-Pro-Ile-Gly-Ser (GPIGS) and another on the somewhat less esoteric Wnt-10b.

— The UK’s Mirror had an excellent article on the dangers of getting bad hair transplants and the importance of picking an experienced surgeon and adviser. Also see my post on the dangers of getting hair transplants in foreign countries such as Turkey.

Pfizer and Allergan have scrapped their merger plans after US tax rule changes limited potential benefits.  I mention this news because Allergan has two important hair loss treatment drugs in the pipeline in Bimatoprost and Setipiprant (search the “Categories” menu on this blog for posts on those products).

New positive PRP and hair growth study from Spain.

— New study summarizing 11 older LLLT studies concludes overall favorable results when it comes to hair.

— Histogen’s Gail Naughton will be making a presentation for 25 minutes in Boston at the 5th Stem Cell Product Development and Commercialization Conference on April 27th at 2:15 pm.

Hasson & Wong updated their topical Finasteride page at the end of March.

— French spiderman climbs an office tower to call attention to hair loss.  Well done monsieur.  The French are supposed to be among the best in the world at realizing the important things in life: for example, hair loss day was celebrated/mourned in the country on March 24th 2016 per the last sentence of that article.

— Someone from the HLT forums asked me via e-mail to help in publicizing a group buy of ingredients to make Dr. Brotzu’s lotion.  I never participate in group buys, and I do not like posting about them since I do not want to be responsible in case someone purchases a dangerous ingredient from some unreliable international vendor. Nevertheless, I will make an exception here and encourage blog readers to visit this link and decide for themselves.  As always, I am not a doctor or medical professional, and I take zero responsibility in case the group buy ends up being something illegal.  I have done no research about the ingredients involved in this group buy.

And now on to medical items of interest:

Salamander’s are known for their limb regenerative abilities.  And now, a team from Australia claims that a stem cell therapy that is capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years due to the development of new techniques.

Garage labs of DIY gene hackers.  I want my own, but am not rich enough to quit working, and am a bit lazy to learn something so different from my day job.  Hopefully some day.

Implant lets paralyzed man play guitar.  I suspect that hair loss and paralysis could both be cured around the same time by the end of 2020 at the latest.

Mind transfer to a computer very possible by 2050.  Very popular story on Reddit based on number of comments, but I think they have this same kind of mind uploading story every single month.

The convergence of programming and biology.

— Two new breakthroughs in diabetes treatment: one makes sense,  but the other is a bit of a surprise.  For probably the 4th time on this blog, I will repeat that the UK’s much maligned gossip rag “The Daily Mail” seems to be at the forefront of covering important hair loss and medical news stories.  I am always impressed by them.

Gene therapy that restores eyesight in some to be tested on humans.  Everyone seems to be having an easier time moving from testing on animals to testing on humans in comparison to hair loss researchers and companies:-(

First 3D printed drug Spritam (for epilepsy treatment) now FDA approved for sale in the US.