Category Archives: Fat Cells

ISHRS 23rd Annual Meeting Begins Today in Chicago

The 23rd ISHRS annual meeting just started today in Chicago, Illinois. Unlike in years past, I did not have time to write a post about this important meeting prior to it commencing.  In any case, I will update this page with more details over the next several days as the conference proceeds.  Here is the schedule of the meeting from September 10-13.

Day 1

— By far the biggest and most exciting news thus far on the first day is Kerastem’s update.  I discussed this company in detail in a post from last year.  In the new update, their small trial on 9 patients in the UK resulted in around a 20 percent hair growth from just 1 injection in all patients.  It does seem, however, that the treatment will not help those that are totally bald.  These results clearly support growing research from recent years that suggests a very strong link between fat cells and hair cells.

Some key quotes from Dr. David Perez-Meza:

The authors reported a 100% patient response rate to the Kerastem Therapy at 6-months.

We are very pleased with these initial clinical outcomes, as they represent results that are on par or better than those of traditional medical approaches to hair loss.

— A really interesting summary of the finally available Okuda Papers from 1939 was presented by Dr. Jimenez.  In those papers, the now deceased Dr. Shojui Okuda covered his own research related to hair transplantation as well as older groundbreaking research from the 1800s!

— Valerie Horsley’s hair follicle stem cells presentation summary.

Day 2

— Dr. John Kahen’s PRP summary — only 1 patient, but great photos. Significant increase in hair density after 6 months and, interestingly, patient saw his light brown hair become dark brown.

— Dr. Jerry Cooley presented something on bio-enhancements.  Link not yet available.

— It was announced on Twitter that this was the most heavily attended ISHRS meeting to date in its 23 years of existence.

Update: Joe Tillman has a good summary of the conference on his website.

Kerastem Technologies — Adipose (Fat) Tissue and Hair Growth

Update: Kerastem’s  website has been revamped and has before and after photos if you scroll down, as well as links to clinics outside the US (e.g., see Japan Kerastem Clinic) where the treatment is already available.  Also, on July 28th, the company obtained conditional FDA approval to commence phase II clinical trials.


On this blog, I have discussed the relationship between hair cells and fat cells numerous times.

Kerastem

One thing missing in the above three posts was a private sector company working on a cure for hair loss based on using adipose (fat) tissue.  That wait has now come to an end.  Last week, a relatively new San Diego based company called Kerastem Technologies submitted a request to commence STYLE clinical trials in order to:

“Evaluate the safety and feasibility of the Celution and Puregraft Systems in the processing and preparation of an autologous fat graft enriched with adipose-derived regenerative cells (ADRCs) in the treatment of early alopecia androgenetica.”

The above link to the clinical trials page has a contact person’s e-mail address on there that I will not publish here.  This contact person is Dr. Eric Daniels, Kerastem’s chief medical officer.

Note that adipose-derived stem cells (ADSCs) are a subset of adipose-derived regenerative cells (ADRCs).

FYI — A Kerastem company video is embedded at the bottom of this post.

Celution & Puregraft Systems

The Celution system is manufactured by a San Diego based company called Cytori Therapeutics.  The US  FDA approved and EU CE-Marked Puregraft system was also developed by Cytori, but divested in 2013 to Bimini Technologies.  I recommend watching the Puregraft video on youtube.  I am now starting to look at my body fat in a less negative way.  Maybe it will end up being more useful than I thought!

Ken Washenik is Involved

One of the world’s most renowned hair loss researchers (that I have covered a few times on this blog) Dr. Ken Washenik is involved in this clinical trial via being the principle investigator. This adds significant credence to these trials, although it should be noted that Dr. Washenik has been overly optimistic about a hair loss cure in the past (e.g., see my post on  Aderans’ Failure or read some of the overly optimistic time-frame related quotes by him in this 2004 article.

Bimini, Puregraft & Kerastem

It should be noted that Bimini, Puregraft and Kerastem are all interlinked, with Bimini seemingly the holding company.  The founder and CEO of Puregraft, Bradford Conlan, is also the CEO of Kerastem and Bimini per his current Linkedin profile.  For our analysis purposes, these three companies are one and the same.

Dr. Eric Daniels and Dr. Craig Ziering

I mentioned Kerastem’s chief medical Dr. Eric Daniels as the contact person for these trials earlier.  Further research on him led to my finding that he presented a paper titled “Hair Follicle Stimulation by Stromal Vascular Fraction Enhanced Adipose Transplantation” in 2014 at an International Federation for Adipose Therapeutics and Science (IFATS) Conference.  Although I could not find that paper online, google gave me a link to this useful thread [40 percent hair regrowth per early results!] that suggests that Dr. Craig Ziering was another author of that same paper.  So now I should take Dr. Ziering and his work on stem cells more seriously in spite of the recent issues with his website.  I wonder if he already has access to the tried and tested Celution and Puregraft systems, giving him a leg up on other hair doctors offering early stem cell treatments?

San Diego, a Biotech Hub

San Diego has become a hotbed of global biotechnology related research, and the hair loss world is no exception.  Kerastem is the fourth (!) San Diego based company that is now listed in the world map of groundbreaking hair loss research work on this site.  The other three are Histogen, Samumed and Sanford-Burnham.

Timeline

Per the comments to this post and on various hair loss forums, it seems like some people are overly pessimistic about the timeline for ADSC and ADRC type treatments.  Surgeons around the world are already treating patients with ADSC, AAPE and PRP.  This kind of treatment will not take too long to come to fruition.