I have covered the work of esteemed and prolific Japanese hair loss researcher Dr. Junji Fukuda for almost ten years. I have also written the below two detailed posts about his findings. The second of these is very lengthy because I have kept updating it for a few years.

• Preparation of hair follicle germs.
• Clinical trials at Yokohama.

Make sure to check out the Yokohama National University based Fukuda Lab’s hair research page.

A Visit to Fukuda Lab at Yokohama National

Reader “Theo” just sent me a link to a very interesting diary of a hair transplant surgeon from Japan who just visited the Fukuda Lab.

Note that while Dr. Fukuda is based at Yokohama National University, the research seems to be taking place at Kanagawa Life Innovation Center (per the above link). One of the images also mentions the Kanagawa Center for Clinical Research & Strategy (KCCR). Yokohama is the second largest city in Japan and is the capital of Kanagawa Prefecture. Check out this PDF of the regenerative medicine sector at Kanagawa Prefecture.

From this visit and summary, I learn some very interesting things. There are three distinct methods in which Dr. Fukuda is pursuing hair regeneration. I mentioned them in my past lengthy post too, but now we have more clarity.

1) Dermal Papilla Cell Transplantation

“Dermal papilla cell transplantation is about to begin in Japan.“

Transplantation of dermal papilla cells (via stratified culture). I assume that the “stratified cuture” in the translation means 3D culturing. Dr. Fukuda mentions that Shiseido already conducted a clinical trial using 2D culturing. In this method, cells are are lined up on a flat surface when culturing, but it only resulted in a 5% increase in hair volume. The 3D method will likely be superior and the clinical trials are about to finally begin! It is hoped to be “put into practical use within five years”.

2) Transplantation of Hair Follicle Primordium

“I think this will take some time.”

The creation of hair follicle primordia means generating hair from scratch. i.e., hair multiplication. I previously discussed the Yokohama team’s process of achieving this via increasing and mixing epithelial cells and mesenchymal cells. These then form “hair follicle primordia“ that are transplanted to the same donor’s scalp in order to regenerate hair in thinning regions of the scalp.

Per the latest feedback from Dr. Fukuda, while this process has already been proven by them in mice, human hair is a different animal. Once the primordium tissue is transplanted to human heads, the direction and length grow haphazardly. He thinks that this will take some time.

3) Transplantation of Regenerated Hair Follicles in Vitro (Organoids)

“It will likely take more than 10 years before it can be used in humans.”

The final method is in vitro regenerated hair follicle transplantation (also called organoid). In this process, hair follicles are regenerated outside the body, lengthened by almost 100%, and then transplanted into the scalp. Per Dr. Fukuda, it will likely take more than 10 years before it can be used in humans.

Other Notes

In March 2023, Dr. Fukuda and his Yokohama team published an important hair regeneration related study. They made an improvement in the expansion of hair follicle stem cells (HFSCs) and dermal papilla cells via the use of a newly designed microwell array device.

The Fukuda Lab has even undertaken research on electric stimulation of human dermal papilla cells for hair regeneration.

So in one day we get two very unique insights and forecasts from Japan! Thanks again to “Theo” for all the stellar non-English language updates from Japan and South Korea.