Category Archives: Aclaris Therapeutics

Regenix and Matthew McConaughey’s Hair Regrowth

Regenix and Matthew McConaughey

— Over the years, there have been numerous rumors on hair loss forums that actor Matthew McConaughey has had hair transplants. However, the actor in the past credited a product called Regenix for his great hair. Mr. McConaughey recently went on the “Live with Kelly” show in the US and credited Regenix yet again with a great review. I have no idea about the ingredients of Regenix since they are proprietary. The manufacturer claims they are all-natural. More on this story here.

— Aclaris Therapeutics’ latest webcast presentation occurred today at the Leerink Partners 6th Annual Global Healthcare Conference. The company’s CEO further elaborated on why they are so optimistic about “highly selective covalently bound JAK 3 inhibitors” helping patients with male pattern hair loss. More importantly, the CEO emphasized on treating female hair loss and how that is even more distressing than male hair loss. You can listen to the whole presentation after registration, and also see the 42 slides in there. For once, someone asked a specific question about covalently bound JAK 3 inhibitors and male pattern hair loss. The most interesting quotes from the CEO:

“Most importantly, androgenic alopecia. Even though that’s traditionally not thought of as an inflammatory process, what they were able to find is that the JAK inhibitors were targeting the stem cell compartment in the hair follicle bulge and actually prolonging and inducing anagen”.

“Being covalently bound…its got a much better shot of not being as promiscous as the other JAK inhibitors”.

— Renowned Singapore based venture capitalist Finian Tan is a major investor in Samumed. I did not realize that he made the decision to invest in the company so suddenly. In his own words: “Only twice in my life I have bet so big on day one”. Poker champion and Samumed CEO Dr. Osman Kibar clearly has some hypnotic powers.

— More developments in finding the genes behind hair loss and baldness. On this blog I have covered several other recent such developments.

— On Hairsite, there is a great question and answer session with Dr. Paul Kemp of HairClone. Dr. Kemp also responded on here a few months ago.

— In the past year, I have posted news about various doctors offering an adipose (fat) cell plus platelet-rich plasma (PRP) combo treatment for hair loss. It seems like this treatment was part of a US based clinical trial. A new article on this subject pointed me towards the main page for the actual website of the trials. They call it STRAAND , which stands for “Stromal Tissue Cell-enriched treatment of Androgenic Alopecia via Novel Deployment”. So far, six doctors are participating. However, unlike in other trials, it seems like patients are responsible for their own expenses.

— A small sample size new study from Italy on non-activated versus activated PRP and the impact of different PRP collection devices on the final result. Dr. Cole from the US is a co-author.

— Replicel CEO Lee Buckler writes his first article for the Huffington Post: “Will 2017 be the year of Cell Therapies?“.

And now on to medical items of interest:

— US patent office hands win in CRISPR battle to Broad Institute and Dr. Feng Zhang.

Human gene editing receives US science panels support. If you have trouble accessing the site, another take here. One day later, a warning from ethicists.

DARPA: We are on the cusp of merging human and machine.

— From the respected “The Economist” magazine: “Printed human body parts could soon be available for transplant“.

— The long quest to create artificial blood may soon be over.

— The tiny robots revolutionizing eye surgery.

Computer lets fully paralyzed patients speak for the first time.

— A lengthy article on Dr. Anthony Atala, with many photos

— First human-pig chimeras created.

Miscellaneous Hair Loss News Items

Hair Loss News of the Month

— A very busy month for Aclaris Therapeutics. First the company updated its product pipeline page and added photos for each dermatological condition. Then they filed for Investigational New Drug Application (IND) for their oral alopecia areata product ATI-50001 with the US FDA. Then, on November 15th the company announced positive results for its topical seborrheic keratosis product (A-101) phase 3 clinical trials. And finally, the company announced a public offering of its common stock. The funds raised from this offering will partly be used towards research and trials for Aclaris’ JAK inhibitor products.

— In the past month, HairClone has added the well known Dr. Russell Knudsen, Dr. Robert Leonard and others to their clinic partner team.

— More good news for alopecia areata/totalis/universalis sufferers. This time its two patients from Brazil who were taking JAK inhibitor tofacitinib.

Wen hair care product lawsuit concludes in favor of customers.

— Sharp (Japan)’s plasmacluster ion technology promotes hair growth. Sounds hard to believe. The ending of the article about reduced dandruff and itching is more believable.

— Cellmid (Australia) raises sufficient funds to start selling its Evolis line of FGF-5 inhibiting hair loss products in the US.

— Hairdresser Chad Gunter is very pleased with his PRP treatment results from Dr. Laura Bennack. According to Dr. Bennack, “the most dramatic results are on men and women who are at the early stages of hair loss”.

— Yet another growth factor (human hepatocyte growth factor) linked to promoting hair growth. Also see my recent post on the various growth factors that benefit hair growth.

— A number of people who are taking Gabapentin are having hair loss issues.

— Missed an important study’s findings last month: BPH drugs such as finasteride and dutasteride (both are also used to combat hair loss) do not raise the risk of erectile dysfunction.

And now on to medical items of interest:

Gene therapy in a box courtesy of the Fred Hutchinson cancer research center.

CRISPR gene editing tested in a person for the first time in China.

“Any idiot” can now create mutant CRISPR engineered mice.

Gene therapy to reverse certain types of genetically inherited blindness could be approved for use as soon as next year.

— And thereafter, bionic superhuman eyes.

— Amazon’s Jeff Bezos partners with the Mayo Clinic and others to enter the anti-aging industry.

— Terminally ill 14 year old in the UK allowed to be cryogenically preserved. Also, a reality check.

— Samantha Payne’s Open Bionics allows anyone in the world to download and 3D print their own bionic limbs.

Brain implants allow paralyzed monkeys to walk. The Swiss scientist goes to China to conduct this work due to friendlier regulations.

— First at-home brain implant allows paralyzed woman to communicate.

Genetically modified pig’s heart transplanted into a monkey in South Korea breaks prior world record. The monkey survives for 51 days. Pig hearts are thought to be a close match to the human heart. Very cruel animal experiments, but hopefully they help humans in future.